MECP2

My research interests are focused on molecular mechanisms of memory formation during infancy. I’m very interested in exploring how experiences during infancy results in hippocampal long-lasting changes, which influence adult behavior. Traumatic early life experiences can predispose individuals to psychopathologies, including post-traumatic stress disorder (PTSD), borderline personality disorder, addiction, depression and anxiety1-4. Paradoxically, episodic memories formed during infancy are…

Abstract The purpose of the case study is to formulate an effective comprehensive multidisciplinary way to treat the symptoms of the condition Rett Syndrome. Identify the current consumer data, disease symptoms and medical history, physical, and mental status of the patient. Once all the data and consumer information is compiled then a treatment plan is formulated using the nursing process. The treatment plan focuses on reducing the symptoms of Rett Syndrome, via the appropriate medication for…

Rett Syndrome is a genetic mutation that is extremely rare and affects mostly girls. Rett Syndrome messes with the brain development, ability to move, speak, and breath normally. About one in every 10,000 to 15,000 girls can get this terrible disease. Other names for this disorder are RTS, RTT, Cerebral Atrophic Hyperammonemia, Autism-dementia-ataxia-loss of purposeful hand use syndrome, and etc. Rett Syndrome is caused by a mutation in a particular gene in the X chromosome. And then that gene…

Rett syndrome is when gene “…MeCP2, a protein that dims the activity of many genes in nerve cells that influence synapse formation or function. The Absence of MeCP2 causes dendrites, tree-like structures on neurons that receive incoming messages, to contain fewer spines, or spots for synapses to grow. The synapses that do develop do not function normally” (Bilimoria). Affecting mostly females this syndrome causes the connections to be extremely weak. Rett syndrome causes slow growth, loss of…

islands methylation levels are low, but when they are turned off, levels are high. Therefore DNA methylation is an inhibiting or gene silencing modification to chromatin structure. When DNA becomes methylated it attracts several proteins including MECP2 and MBD1 which recruits histone modifying enzymes to remove acetyl or add methyl modifications on histone tails. This allows the open chromatin to condense as nearby histones fold to block transcription from occurring. DNA methylation can…