Mast cell

most common health conditions. They begin when an allergen, the substance responsible for the reaction, causes the production of immunoglobulin E (IgE) antibodies, which coat mast cells. On subsequent re-exposure to the allergen, IgE reacts and causes the release of histamine and other inflammatory products from mast cells. These released substances lead to several of the signs and symptoms associated with allergies. Patients may have experiences that range from mild and uncomfortable to…

Itchy eyelids Overview- Itchy eyelids can occur from any situation that inflames, irritates or infects our eyelid. Infections, allergies, and even deficiency of sleep can reason your eyelids to itch. Itchy eyelids are usually related with other symptoms like swelling, redness, a realistic feeling in the eye, irritation, bumps or lumps, improved tear development, or discharge. Allergies are the most common reason of itchy eyelids. An allergy that impacts your eyelid may be native, like an…

There are four subtypes of HRs ranging from HR1 to HR4. HR1 are coupled to Gq/G11 protein and are located on the membrane of CNS neurons, smooth muscle cells, CVS, neutrophils, eosinophils, monocytes, macrophages, DC, T and B cells, endothelial cells and epithelial cells. HR2 are coupled to Gs protein and are located in primary gastric parietal cells, smooth muscle and CVS. HR3 and H4R are coupled to Gi/o protein and are distributed around the body. HR1 are the major…

Introduction Allergy shots, also known as allergen immunotherapy, is a treatment that helps reduce allergy symptoms such as: Sneezing. Itchy, watery eyes. A runny, stuffy nose. Asthma. The treatment may benefit children who are allergic to any of these substances: Grass, tree, plant, and weed pollens. Stinging insects. Animal dander. House dust mites. Molds. The treatment is not done for food allergies. During your child's allergy immunotherapy treatments, the substance your child is allergic to…

which antihistamines take throughout the body once ingested, and this article houses the answer. Aside from that individual question, this source contains information regarding the histamine receptors and the effects they play on different types of cells located throughout the body as a whole. This article was published in a journal and was been revised so the creditability is solid, but this article is written in the form of a secondary source. The bias is a little hard to locate because of the…

Introduction: I. Attention Getter: Nicole Levin, a 41 year old New Yorker, was leaving the dentist when it happened. Her throat began to swell and breathing became difficult. She could not swallow and she felt extremely nauseous. Levin knew at this point what was happening. She was having an allergic reaction to medication the dentists prescribed her. Frantically searching in her purse, she clutched her EpiPen and she could breathe again. Nicole’s story, found on CNN, published by Jacqueline…

Food Allergies On the Rise Throughout the past fifteen years the amount of people effected by food allergies has concerningly increased. In a research release in 2013 by the Centers for Disease Control and Prevention, between 1997 and 2011 there has been a fifty percent increase in food allergies among children under the age of eighteen. Every three minutes a food allergy reaction sends someone to the ER. Why we are not worried? Research estimates up to 15 millions of Americans have food…

Since food allergies are a problem that affects so many people there are few options that can not only benefit but, improve the lives of all Americans. Those few options are creating a law the requires the display of food allergy awareness poster in all food service establishments and in addition, also requires employees to be trained in food allergy awareness. Another possible solution would be to make EpiPen® (epinephrine injection, USP) an accessible access for those in restaurants since…

Correlation between Mast Cells & Liver Disease Introduction: Our guest speaker was Heather Francis PhD who works at both Baylor Scott and White and adjuncts at Texas A&M University. She is a research scientist who has dedicated her studies into the correlation between mast cells and liver diseases. Dr. Francis, along with her research team, has found a link between some hepatic pathologies: cancer and cirrhosis, and an increase in the number of mast cells. Paracrine Interaction: Dr. Francis…

surface of mast cells that result of systemic release of vasoactive amines and other mediators from mast cells. The presence of IgE antibody indicate that this is not the first exposure to this antigen. The mast cells have a specific receptor for the Fc portion of IgE called FceRI (a high-affinity receptor). When IgE binds to mast cells the cell became sensitized and activated. However, these mediators such as histamine, tryptase, heparin, chymase, and cytokines are stored in the granules of…