Malignant hyperthermia

Silent, but Deadly 2 Abstract Malignant hyperthermia is a very rapid onset crisis that happens during a surgical procedure. It is unnoticeable and is an adverse reaction to anesthesia that was given in either form of volatile agents or succinylcholine. It is undetected in most cases unless having been tested for this particular type of reaction either through muscle biopsy or genetic testing. The reason for the absence of detection in most cases, is that the only way to trigger malignant hyperthermia is inducing in the patient via the triggering anesthetics. Treatment for malignant…

Malignant hyperthermia is an autosomal dominant disorder that affects the muscles and metabolism in reaction to certain anesthetic gases and succinylcholine (Huether, 2012, p. 986). Individuals affected by this disorder carry a defect on the ryanodine gene (RYR1) (Gisolfi, 2000). This receptor on the skeletal muscle cells is found on the calcium release channels of the sarcoplasmic reticulum (Eilers, 2012). Certain anesthetics such as inhalation anesthetics of halothane, sevoflurane,…

This condition was in one of the clinical correlations which I thought was interesting how the body’s energy processes worked against themselves. Malignant hyperthermia (MH) is a rare, inherited life-threatening condition that is induced by general anesthetic drugs such as halothane. Generally, most cases show no signs or symptoms until individuals are exposed to anesthesia. However, there are cases where an individual with MH goes under anesthetics and will not react. The reaction includes a…

There are many definitions of thermal comfort, which depends on the aims and expectations of those who defined it (Chappells, and Shove, 2004). Jiao (2010) stated that, the rate at which human body gain and lose energy, and also the state of comfort is satisfactory once all heat flow in and out of the body are in equilibrium. Also, (ASHRAE 2004), described it as “the state of mind that expresses satisfaction with the surrounding environment.” This definition highlights subjective and…

The article that I choose was called “Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest”. The objective of the article was to find at which temperature was it better to induce hypothermia on a patient who had gone into cardiac arrest in an out-of-hospital scenario to prevent neurological damage and the. The researchers hoped that if by inducing hypothermia early on after the cardiac arrest and loss of consciousness there would be little to no brain damage. The researchers…

At Home Care and Avoiding Heat Stroke Heatstroke is the most serious of the heat-related conditions typically known as heat cramps, heat exhaustion, and heat stroke. Heatstroke is a critical condition requiring immediate medical attention. According to WebMD, if it is not treated in time, it can damage the brain, heart, kidneys' and muscles. In a short time, heat stroke will lead to death. Heat stroke is contrasted from the serious but not usually fatal heat exhaustion in a couple of ways.…

However, many athletes practice in hot and humid weather conditions which intensify the test that physical exercise places on the thermoregulatory processes. The hot and humid setting weakens the heat exchanges between the body and the environment considerably. The struggle between the body and environment can lead to serious heat illnesses in athletes, such as, heat stroke, dehydration and heat exhaustion (Wendt, 2007). When an individual exercises, their core body temperature increases from…

This could occur due to the electrical control of smooth muscles and the enteric nervous system which control the gastro intestinal track. The bowel motion at several levels of innervations can be affected. The post ganglionic fibers in the brain can affect the activities of smooth muscles in intestinal area causing contraction which could result in constipation or relaxation of sphincters leading to diarrheal condition. Auto immune disorders like hepatitis, cirrhosis are common in smooth…

Depolarizing relaxants are associated with life threatening hyperkalemia and non-depolarizing neuromuscular blocking drugs may lead to a prolonged effect (3). Some controversy about the use of volatile anesthetics and their potential to cause a malignant hyperthermia-like syndrome or rhabdomyolysis exists (4). Therefore, regional anesthesia may offer advantages for avoiding many of these problems with reduced drug doses, avoidance of tracheal intubation and decreased postoperative opioid…

Keywords: neuromuscular, genetic, chloride channel, myotonia congenita, Thomsen’s, Becker’s, anaesthetic management, general anaesthesia, TIVA, non-depolarising muscle relaxant, laparoscopic surgery Abstract: Administering anaesthesia in a patient with nerve and muscle disorders is tricky due to multiple challenges- the unpredictable effects of neuromuscular blockade and dreaded risk of malignant hyperthermia. We present the management of a case of Myotonia Congenita, with an ovarian dermoid and…