Macrophage

on the regulatory hormone that is produced in the liver, known as hepcidin. Hepcidin helps regulate body iron homeostasis by determining the magnitude of dietary iron release from the enterocytes and stored iron release from reticuloendothelial macrophages (Feng, 2012). When activated it regulates the degradation of Ferroportin which is responsible for the transport of iron throughout the body. Normally hepcidin concentrations will increase in the presence of inflammation and iron overload…

The human body consists of multiple systems working together to keep us alive and well. These systems include: the skeletal system, muscular system, cardiovascular system, digestive system, respiratory system, reproductive system, nervous system, endocrine system, urinary system and immune system. Each of these systems has its own role in allowing our body to function appropriately. However, each is interdependent. Therefore, if one system becomes compromised for any reason, other body systems…

If a patient is already a diagnosed asthmatic, the rhinovirus can induce an attack through causing higher levels of neutrophils to the bronchi than in normal patients (Zhu et al., 2014). This severe macrophage intrusion, and cellular inflammation creates a higher risk for the patient to develop an asthma attack (Zhu et al., 2014). In patients without asthma, having repeated HRV infections with a recurrent wheeze causes airway inflammation and remodelling…

The detrimental health affects caused by smoking tobacco have long been known in our society. Tobacco smoke is composed of a complex, chemical mixture of roughly 60 known carcinogens (Alexandrov, et al., 2016). Smoking tobacco and exposure to other carcinogens increases human risk for cancer significantly by enhancing DNA mutation rates. Different carcinogens cause slightly different types of DNA damage in humans that eventually lead to cancer (Ehrenberg, 2016). These unique patterns of…

Sickle -cell anemia is a disease that affects the shape of red blood cells and it causes them to become a sickle shape. Sickle cell anemia was first noticed around 1670, in a tribe called Krobo in Ghana, Africa. In 1910 a physician in Chicago named James Herrick was the first person to first describe it clinically (Kiple). Since then much more information has been discovered on this disease. Such as this is a disease that people inherit from their parents if both are carriers. There are many…

About the size of a large fist, heart is made up of cardiac muscle, myocardium, with skeletal muscle-like striations. It has two upper atria & two lower ventricles separated vertically by septum, and four main valves with which the blood makes its directional flow into and out of the heart. Deoxygentated blood with which the blood flows into and out of the organ. Deoxygenated blood enters through the venae cava fills the right atrium (RA) and right ventricle (RV) through the tricuspid valve.…

1. Definition of Asthma: Asthma is one of the most common type of chronic obstructive pulmonary disease (COPD). A COPD is a type of disease or disorder to which the airway is affected and causes breathing to be slowed or forced. Asthma is a type of COPD that causes the airway to become inflamed and to be hypertensive (increased pressures in the blood vessels in the airway) due to any internal or external stimuli. The system that is closely associated with asthma is the respiratory system. The…

The player suffering the syndesmosis injury is an amateur rugby player aged sixteen years old male and is still in high school. The player is young and puberty is still occurring therefore, growing cartilage is more vulnerable to stresses compared to adults where cartilage has formed (Adirim and Cheng, 2003). This suggests that young adolescents are more susceptible to injury because stresses to growth plates can severely affect coordination and balance, resulting in poor motor skills (Wulf and…

Mummification is a modification of putrefaction characterised by the dehydration of the tissues converting the body into a leathery mass of skin and tendons surrounding the bone. The internal organs are often decomposed but preserved. Skin shrinkage may produce large artefactual splits mimmicking injuries, particularly seen in the groins, around the neck, and the armpits. Mummification develops in conditions of dry heat, especially when there are air currents,e.g. in a desert or inside a…

Unique microorganisms reside on and within tissues and body fluids of mammals, and are known as the commensal microbiota. It is estimated that the human body contains 3x1013 eukaryotic cells and 4x1013 bacteria (1). By early adulthood host cells are outnumbered by microbial species by 100 fold (2). These microbes are far from neutral bystanders, and are suspected to influence the developing immune system in responses from cytokine balance, to lymphocyte responses, to antibody induction (3). In…