Our logic for choosing kinesin for developing CNS therapeutics is based upon our own research, which found that kinesins are transcriptionally upregulated during memory storage and that they are both necessary and sufficient to induce long-term memory storage (LTM) in the marine snail, Aplysia californica (Puthanveettil et al., 2008; Fig 1). Furthermore, other researchers have also discovered that an increase in specific kinesin function in the mouse forebrain improves working memory (Wong et al…
The information stored in the long term memory can take many forms. However, most long- term memory can be categorized into one of the several types: episodic, semantic, procedural and emotional memories Episodic memories are memories of specific event that happen to you, and can be easily told to another person. Usually these memories come from personal experience. Episodic memories can be compared to a diary that let you go back in time and let you retrieve a personal…
experiences, along with the accompanying emotional tone, into memories. The function of memory includes three components: encoding, storage, and retrieval. If any link in the chain is defective, memory can be impaired. Memories are held in short-and long-term “storage.”…
dells become the dominating feature of the landscape. Within the dells, nature is more secluded and has to adjust to the presence of people. The rabbits scamper to safety and the birds stop singing simultaneously when they are disturbed but before long they continue their day-to-day routine. The excess of plants, trees, and wildflowers provide a variety of different scents. The dells begin to mix more with the deciduous cottonwood trees that grow near all of the little stagnant murky ponds…
common models of memory is “The Modal Model.” This model represent memory in three structural features: Sensory storage (hold a lot information for seconds), Short-term memory, which also known as working memory (hold information for 5-7 seconds), and Long-term memory (holds information for years/decades). In slide 9 it exposes one way memory loses retrieval velocity. This stems from the idea of the Time-Dependency Principle, “Memory for an event is an inverse (negative) function of the…
brain is that of a computer. New bits of information are written in a particular location, and stored in the hard drive. For a better example, encoding of a memory is like hitting save on a computer file. Once the file is saved, it can be retrieved as long as the hard drive remains…
disease (Boeree, 2009). The α-7 nicotinic acetylcholine receptors (α7- nAChRs) are highly expressed in the hippocampus (Prickaerts et al., 2011). Hippocampal long-term potentiation (LTP) is the constant increase in the efficiency of synaptic transmission. Research supports the hypothesis that α-7 nAChR agonists improve LTP and the formation of long-term memory in animal models due to the activation of the MAPK signaling pathway, with phosphorylation of ERK and CREB. α-7 nAChR agonists also…
remember doing or seeing something, and wonder to yourself how on earth did I remember that? Well, in this paper I will try to help you get a better understanding. I will explain how things you do, see, or hear become a memory. I will also discuss long term and short term memory along with why and what makes you forget. There will also be a page about amnesia , and the different systems and types of memories. I know at first it doesn’t sound that interesting, but if you just give it a chance I…
person carries, which include: joy, sadness, anger, fear, and disgust. These five basic emotions not only control Riley’s life, but her memories. Most people don’t know this, but our memories are structured in a certain way. They may be separated by long-term or short-term as well as a joyful…
An average person can remember things that happen in their lives whether it be for a short time, or a long time. There are many factors involving the memory of the brain such as sleep. The human brain is a unique and amazing place where one can store things about their life. Some would say, that the human memory is like a huge library of moments stored throughout our brains. In my opinion, this is a great process is that if we are experiencing something new in our life, we can go and look up a…