Liquid chromatography-mass spectrometry

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  • Analysis Of Losartan Potassium

    2-n-butyl-4-chloro-1-[2- (1H-tetrazol-5 yl) biphenyl- 4-yl) methyl] imidazole-5- carboxyl acid)[1]. The determination of Losartan has been carried out in tablets by HPLC, capillary electrophoresis and super-critical fluid chromatography[2,3], in urine by gas chromatography- mass spectrometry[4] and, simultaneously with its active metabolite in biological fluids, by HPLC[5- 10]. Amlodipine Besylate (ADB) )[FIG.1.B], chemically,…

    Words: 1564 - Pages: 7
  • Chemical Disinfection Methods

    into contact and reacting with natural organic matter (Bougeard et al., 2010). With the amounts of hazardous chemicals being in such minute quantities, a reliable detection method is required. This can be achieved through the use of chromatography and mass spectrometry. Through these methods of detection chemical compounds can be isolated and identified while giving accurate…

    Words: 1502 - Pages: 7
  • Papaveris Pericarpium

    The main active components of MOR and COD in plasma and urine were quantified by a validated high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method. The PK parameters of each component was obtained and compared after different oral dosages. Multiple-dose studies were performed to explore the drug accumulation, and urine drugs were also analyzed to evaluate…

    Words: 768 - Pages: 4
  • Forensic Science Essay

    poisoning, fatal or otherwise. In ancient times the tribal and primitive men used to paint the arrow heads to render the more effective and killing their enemies, men and animals. Though it is very hard to define “poison” but it is a substance (solid, liquid, gas) which if introduced to the living body or brought in contact with any part there of produces ill health or death or both, by its’ constitutional or local effects or both. Again many substances which are harmless and is essential for…

    Words: 1602 - Pages: 7
  • Factionation Of ABE Extract By Column Chromatography Case Study

    Natural products either as pure compounds or as standardized extracts provide unlimited chances for new drug discoveries because of the unmatched availability of chemical diversity (Cos et al., 2006). According to the World Health Organization (WHO), more than 80% of the world's population trusts on traditional medicine for their primary healthcare needs. Plants used for traditional medicine contain a varied range of compounds that can be used to treat chronic as well as infectious diseases…

    Words: 845 - Pages: 4
  • Pyrenehexanoic Acid Synthesis Lab Report

    The second step of forming the amide also required TLC, and was done using the same reagents, ethyl acetate and water. The spots, however, on the plate could not be differentiated visually, and thus the reaction may not have run to completion. Mass spectrometry was used instead, and it was determined that the reaction had failed by producing a…

    Words: 1556 - Pages: 7
  • Neurocognitive Assessment: Neurocognitive Analysis

    with Dr. Tilla S. Worgall and/or in the Laboratory of Toxicology and HPLC of the Department of Clinical Laboratories, Pontificia Universidad Católica de Chile. Sphingolipid levels will be quantified by high performance liquid chromatography-triple quadrupole-tandem mass spectrometry (HPLC-MS/MS) on an Agilent 1200 HPLC system, equipped with an Agilent C18 column as described in protocol implemented and validated by our group2. Sphingolipid profiles will include the following molecular species:…

    Words: 308 - Pages: 2
  • Gas Chromatography Method

    Several methods have been described in the literature for the determination of MNT in its pharmaceutical dosage forms or in biological samples. Examples of these methods in biological samples are gas chromatography – mass spectrometry (GC-MS) [18] in plasma and urine of rats and human while GC-FID [19] was used for MNT analysis in human urine. Also, MNT in mixture with other drugs have been assayed in human plasma using GC-FID [20]. In pharmaceutical preparations…

    Words: 945 - Pages: 4
  • Lovastatin Research Paper

    with trypsin overnight forming peptides. The peptides were extracted with 5% acetic acid in H2O and 5% acetic acid in CH3CN/ H2O at a 1:1 ratio, dried and stored at -200C for further analysis. B) Protein Identification A high performance liquid chromatography separation was used in presence of homemade trapping column and separation column. Both the column were packed with ReproSil-Pur C18-AQ resin. The determined peptide mixture was loaded into the trapping column with a solvent mixture of…

    Words: 1599 - Pages: 7
  • Bioanalysis In Biopharmacenology

    Introduction: LC-MS is used for the bioanalysis of small molecules drugs, which has molecular mass of less than 800 Da. Now a days, it is also frequently used for the bioanalytical determination of biopharmaceuticals.1 In pharmaceutical R & D, it takes a year to develop a new marketing drug identified from thousands of new compounds. The drug discovery is divided into early and late phase, during which pharmacokinetics study or bioanalysis of a drug is done. Once, the bioanalysis of a drug is…

    Words: 1888 - Pages: 8
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