Limb-girdle muscular dystrophy

Duchenne muscular dystrophy (DMD) is a one type of muscular dystrophy. Muscular dystrophy is a group of genetic disorders, leading to progressive muscle degeneration. People suffering from most common muscular dystrophies ,Duchenne/Becker (DMD), Myotonic (MMD), and Limb-Girdle (LGMD), experience muscles degradation overtime, leading to overall muscle weakness and decreased mobility. Statistics show that the most prevalent forms of muscular dystrophy are rare. For example in 2007 in the…

team of researchers decided to screen 23 affected individuals for mutations of the Lmna gene. They chose the Lmna gene due to its involvement in a wide spectrum of heritable disorders including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, and Charcot-Marie-Tooth disease (“Lmna”). The decision to screen the Lmna gene definitely paid off, as three different mutations were discovered. The mutations encompassed the substitution of just one…