Limb-girdle muscular dystrophy

Myotonic Dystrophy is an autosomal dominantly inherited disorder at which an individual has the inability to relax his or her muscles; thus progressing to muscle degeneration and decrease muscle tone [1]. Currently there are two types of muscular dystrophy that are known in the both the medical and scientific community. There’s type one myotonic dystrophy also known as congenital myotonic dystrophy which has an onset at birth. Then there is type two, myotonic muscular dystrophy which has an…

Duchenne muscular dystrophy (DMD), the most common form of all muscular dystrophies, is an X-linked disorder affecting approximately one in 5000 newborn boys. "(page1; paragraph 1; lines 1-4)" Patients are usually restricted to a wheelchair around the age of twelve and facing death somewhere between the ages twenty-five to thirty. DMD is caused when the dystrophin gene is mutated. That mutation stops the communication for a functional protein. The inadequacy of dystrophin causes muscle fiber…

Muscular dystrophy is a type of hereditary disorder that can cause muscle weakness and can ultimately lead to the decay of skeletal muscles. A diagnosis of this disease can create a reduced quality of life and the inability to perform basic day-to-day function. Since this disease is genetic and is caused by a mutation, it is more likely for an individual to be diagnosed if a previous member of the family has had it before. The most common type of muscular dystrophy is known as Duchenne Muscualr…

Muscular Dystrophy is a disease which leads to muscle weakness and loss of strength. This disease begins at an early age and symptoms appear during the early stages of childhood and it progressively destroys and deteriorates the muscles. Among the many types of Muscular Dystrophy, the most common and severe form is Duchenne Muscular Dystrophy (DMD). Duchenne Muscular Dystrophy is an inherited disorder and unlike other forms of Muscular Dystrophy, it is the one that develops and worsens quickly…

Duchenne Muscular Dystrophy In this world, there are many diseases that are being caused by the X chromosomes or the Y chromosomes. Some of the diseases could be passed down from generation onto the next because it is gene and some of the diseases can be treated and which later on causes for it to make it worse. The diseases that would always be there would be Down Syndrome, Huntington’s Disease, Hemophobia, and many more. As you can see, this paper is going to be able a genetic disease that is…

Duchenne Muscle Dystrophy Introduction: “Muscular Dystrophy is a group of muscle diseases that weaken the musculoskeletal system. Muscle Dystrophies are characterized by muscle weakness, defects in muscle proteins and the death of muscle cells and tissue. Duchenne Muscular Dystrophy is one of many types found and it passed down through the X chromosome. DMD is one of the most common muscle diseases found in early childhood. 1 in 3500 boys are born with DMD however very rarely affects girls…

Muscular dystrophy is an ailment that can have a very huge toll on the body. It is a group of congenital muscle diseases, in which muscle fibers are strangely vulnerable to mutilation and become increasingly weaker. In the late phases of the disease, fat and connective tissue often swap muscle fibers. This disease usually appears to be because of a hereditary shortage of the muscle protein, dystrophin. This group of ailments includes Duchenne's muscular dystrophy, Becker's muscular dystrophy,…

The LMNA gene (1q21-22, MIM 150330) encodes two proteins of the nuclear envelope – lamin A and C. They are intermediate filament proteins necessary for function and structural integrity of the nucleus. Lamins consist of an amino-terminal head domain, a coiled-coil central rod domain and a carboxy-terminal tail domain (Fig. 1A). They form dimers by rod domains and then associate in head-to-tail polymers creating complex network conjunction with other proteins located underneath the inner membrane…

There are about 700 types of muscles within the human body that aid the body with movement while a few also helps with stabilizing the bones (Allen and Harper 2014). Skeletal, cardiac, and smooth are the three types of muscular tissues found within the body (Tortora and Derrickson 2014). The heart is made out of cardiac muscle tissue and that is striated (Tortora and Derrickson 2014). The walls of the hollow organs of the human body are made with smooth muscle tissues that are non-striated…

differentiation or myogenesis. Also through intramuscular transplantation of human skeletal myogenic progenitors derived from PSCs, it creates and engraftment that adds to the satellite cells present. Additionally the removel of PSCs derived from patients with muscular dystrophie that are differentiated into satellite cells and mesoagioblast like cells. These cells have been genetically corrected and once reintroduced into dystrophic mice, it repairs their dystrophic phenotype.…