Ligand

biophysical that I aspire to focus on during my graduate studies. I am greatly interested in biochemical pathway elucidation and structure-based drug design by understanding the specific molecular interactions of essential enzymes in complex with various ligands, which can be used for the development of effective and potent inhibitors of drug targets. My desire to continue my education via pursuit of a Ph.D. is strengthened…

Imprecision The lowest coefficients of variation for precision within and between series over the whole tested concentration range were found for the LIAISON CLIA and LC-MS/MS method. Then followed the RIA. The Immulite CLIA showed the highest overall values and thus the lowest precision. A detailed list of all calculated variation coefficients is provided in Table 1 (A). Sensitivity The limit of blank (LoB), limit of detection (LoD) and limit of quantification (LoQ) were determined for all…

Chapter 1 Atherosclerosis Structure of the normal artery: Cell types composing the normal artery: Endothelial Cells: The endothelial cell (EC) of the arterial intima constitutes an important contact surface with blood. It plays an important role in vascular homeostasis. This blood compatibility is due to presences of heparan sulfate proteoglycan molecules on the surface of the EC. These molecules can serve as a cofactor for antithrombin III, which inhibit thrombin. The surface of the EC also…

Cover Page Name: Ramez Aiman Ramses Metias Student ID: RAMRD1503 CHEM 1300 Instructor: Dr. Shaune Mcfarlane Room Number: 216 Locker Number: 1137 Rotation : 1 Experiment: #4 Title: Copper Cycle Experiment Date: 31st may 2016 Experiment Time: 1: 30 pm Purpose This lab experiment is divided into two parts A an B . In part A , we will start with our given solution of and synthesize a number of copper compounds by chemical reactions and observing every colour change and…

Haloperidol and Quetiapine In modern medicine, there are two main groups of antipsychotic medicine such as, conventional antipsychotics (1st generation antipsychotics) and atypical antipsychotics (2nd generation antipsychotics). Haloperidol is a conventional antipsychotic which is used to treat schizophrenia and some other forms of psychosis. Haloperidol was developed in the late 1950s by company Janssen, and approved by the U.S. Food and Drug Administration (FDA) in 1967. (David A. Williams )…

Nanoparticles (NPs) have piqued the interest of scientists because of their distinct physical, chemical and biological properties when compared to bulk material. These differences in characteristics can be attributed to the high surface-to-volume ratio (SA:V) of NPs compared to bulk material. Since NPs have a higher SA:V than bulk material, they are more reactive than their bulk counterparts; therefore, the surface characteristics of NPs can be easily manipulated. (Xuefei et al, 2014) Metal NPs…

Detailed focus question: What is the process of self-renewal and duplication in breast cancer stem cells through E113, the Wnt-beta catenin signaling pathways and the tumor regulator p53? I. Introduction: To explain the cellular and molecular features of my focus question I will provide background on cancer stem cells, some of the various signaling pathways and breast cancer specifically. A. Cancer Stem Cells (Tumor-initiating cells) 1. Basic Features: Have the capacity to self renew and the…

AIMS AND OBJECTIVES: To find out the most effective dose of nalbuphine as adjuvant to spinal anaesthesia. To compare the three different doses and find out most optimum dose of nalbuphine with minimal side effects and maximum analgesic effect. MATERIALS AND METHODS: We conducted prospective randomized double blinded controlled study with 120 ASA I and II patients who were undergoing lowerlimb orthopedic surgery under spinal anaesthesia. We randomly allocated four groups A,B,C to receive 0.4, 0…

Comparing with other disabilities, diseases, spinal cord injury is a critical disorder in worldwide. Physiology and anatomy The spinal cord(SC) is a grayish-white structure that begins superiorly at the foramen magnum in the skull, where it is continuous with the medulla obolongata of the brain. It terminates at the level of the lower border of the first lumbar vertebra. The spinal cord is located within the vertebral canal of the vertebral column, which is surrounded by three meninges: the…

ALZHEIMER’S DISEASE In 2015, there were approximately 48 million people worldwide with AD. It most often begins in people over 65 years of age, although, 4% to 5% of cases are early-onset Alzheimer’s, which begin before this. It affects about 6% of people 65 years and older. It was first described by, and later named after, German psychiatrist and pathologist, Alois Alzheimer in 1906. (http://www.alz.co.uk/alois-alzheimer) In 1906, Alzheimer gave a lecture that made him famous. Alzheimer…