Ligand

tract The inhibition efficiency of polymers are highly dependent on group functionalities as well as adsorption characteristics, electronic properties, and molecular weight. The modification of these properties pave the way for future research in inhibitor technology. Introduction The inherent protection of metals and their alloys used in industry are of the upmost importance when it comes to longevity and reliability of structures. Many chemical compounds have been developed over the years…

Scheme 3. Substrate scope of the Mannich reaction of 5 to α-amido sulfone 3. Reactions were performed with 5 (0.1 mmol), 3 (0.12 mmol), KF (0.3 mmol), and (R)-1b (10 mol%) in o-xylene (1.5 mL) at 25 °C. The yield was determined after chromatographic purification, and the ee value was determined by HPLC analysis using a chiral stationary phase. Diastereomeric ratio was determined by 1H NMR. To demonstrate the scalability of the process and the application potential of the resulting chiral Mannich…

Chemistry is the field of science involving structures, composition, and properties of substances and matter in order learn how they interact with each other. However, disposing and making chemicals can cause hazard to the environment and wildlife. In “Chemistry: Green and Clean,” Jennifer Weeks builds an argument to persuade her audiences that green chemists are working cooperatively to develop a field of chemistry that can replace polluting technologies. Weeks uses alternative ways to…

Sickle cell anemia (SCA) is a classification of the most common form of sickle cell disease. This class of sickle cell disease is genetic and is caused by the homozygous mutation of the beta-hemoglobin gene (beta S allele) in red blood cells [2]. Individuals who are diagnosed with sickle cell anemia have deformed (sickle shaped) red blood cells that have a lower lifespan [3]. This causes irreversible tissue damage and causes a vaso-occlusive crisis, which is pain in the abdomen, bones and chest…

various industrial processes such as biofuels like bioethanol, lactic acid and single cell protein, through saccharification lignocellulosics or hydrolysis of cellulosic biomass, triphasic biomethanation, plant waste management, chiral separation and ligand binding studies (Salunke, 2012). Other fields of interest are textile, laundry, paper, fruit juice extraction and animal feed activities. Also, the sources of cellulose…

Assistant Professor of Pharmacology. NIH funding and publications in ligand-receptor interactions. ○ Karen Houseknecht Ph.D. Professor of Pharmacology. Over 50 publications on Pharmacology and Addiction. Co-I on NIH U01 award. PI on several R01s. ○ Glenn Stevenson Ph.D. Associate Professor of Psychology. NIH funding…

2.0 Experimental Approach Predatory cone snails (genus Conus) produce a rich array of venoms that collectively contain an estimated 100,000 small, disulfide-rich peptides (i.e., conotoxins, or conopeptides). Over the last few decades, the conopeptides have revealed a remarkable diversity of pharmacological function and utility. An evolutionary rationale for the existence of such a large and pharmacologically diverse set of gene products can be premised on the complexity of intra- and…

Cannabis, or cannabis sativa, originated in Central Asia and has been used for its psychoactive properties for many years (Iversen, 2008, p. 6). It affects the brain of adolescents and adults differently through the binding of CB1 receptors due to distinctions in neurocognitive development. There are certain changes in gray and white matter densities, brain volume, as well as endocannabinoid concentrations. This creates aberrations in cognition and memory performance. Cannabinoid’s structures…

3.2. Molecular Electrostatic Potential (MEP) surface of Pyrazolooxazines. The correlation between the molecular structure and the physicochemical property of molecules, including biological molecules and MESP-based drugs, to distinguish electron rich zones (electrophilic attack) from electron-poor ones (a nucleophilic attack) 16, 17. We represent in this study the molecular surface of the electrostatic potential (MESP), the electrostatic potential (ESP) and the electron density (ED). MESP is a…

their respective complexes the density is weaker and broken for the longer fatty acids. The location of site 2 is between the sub-domains IA and IIA. Site 2 is made of the fatty acid binding sites on HAS. In this site, the carboxylate moiety of the ligand is shielded from solvent. The density at this is conducive for all the fatty acids. Site 3 and 4 contain two molecules of C14:0. The molecules are bind at right angles with their methylene tails in contact. However, site 4 is longer and…