Isomer

2.5. Statistical analysis Multivariate analysis was performed using two algorithms: PCA and 2-D HCA heat map. The PCA, based on the correlation matrix, was performed using XLStat-Pro 2015 software. The 2-D HCA heat map was carried out with the ArrayTrack, and the Ward's minimum-variance method was used for runs and hydrocarbons clustering. A probability level of p=0.05 was considered as significant difference. The data obtained from the RSM on the hydrocarbon removal were subjected to the…

Abstract Bacteriorhodopsin is located in the plasma membrane of Halobacterium halobium, where it acts as a proton-pump, transporting protons out of the cell. Since its discovery in 1979, much research has been done on Bacteriorhodopsin and there have been many advancements in our knowledge. Firstly, on its structure and function and secondly, on the conformational changes it undergoes during retinal isomerisation. Introduction Bacteriorhodopsin is a globular protein, (Henderson, 1975) which…

Sirtuins and Histone deactylases (HDACs) Eukaryotic DNA is packed in a high level structure called chromatin, resulting from the assembly of an elementary unit, the nucleosome, and an octameric structure obtained from eight proteins called histones [1]. Histone deacetylation is a reversible process whereby histone and non-histone protein transfer the acetyl moiety from acetyl co-enzyme A (CoA) to lysines while histone acetylation is the direct opposite process whereby acetyl groups are removed…

Chapter 1: Introduction 1.1 Nature of the Dissertation Identification, quantification and analysis Amoxicillin and Flucloxacillin Sugar free antibiotics which are manufactured at Athlone Laboratories by high liquid fluid chromatography (HPLC). The project also involves Method Transfer validation by analysis Amoxicillin Sugar Free for the new project of GSK Mayenne France, this involved Identification, quantification and analysis of carrying Amoxicillin Trihydrate API and Sodium Benzoate in…

reached the bottom. This was due to small amount of pigment obtained during filtration after drying. Iodine was added after examining the Lycopene sample using UV spectrum which was to Isomerise the Lycopene sample to mixture of both cis and trans Isomers. This solution was then…