Ischemia

system, principally cardiac disease, vascular diseases of the brain and kidney, and peripheral arterial disease. The causes of cardiovascular disease are diverse but atherosclerosis and/or hypertension are the most common. In addition, with aging come a number of physiological and morphological changes that alter cardiovascular function and lead to increased risk of cardiovascular disease, even in healthy asymptomatic individuals. Heart attacks and strokes are usually acute events and are mainly…

According to “Essentials of Pathophysiology” by Carol Porth, “sickle cell disease is an inherited disorder in which abnormal hemoglobin (hemoglobin S [HbS]) leads to chronic hemolytic anemia, pain, and organ failure”. The recessive gene is inherited and appears as the sickle cell trait if heterozygous or sickle cell disease if homozygous with two HbS genes. The amount of hemoglobin that is affected by the gene depends on if they are heterozygous or homozygous, and therefore affects the gravity…

Stroke is a cerebrovascular accident with sudden onset of focal neurological deficits(s) from either infarction or hemorrhage within the brain. • Ischemic stroke (thrombotic or embolic); 87% • Hemorrhagic stroke (intracerebral or subarachnoid); 13% Risk factors • Age: >45 years; highest during the 7th and 8th decades • Male > Female (3:1), equalizes after menopause • Family history/genetics • Prior stroke or TIA • Smoking, heavy alcohol use, substance abuse (cocaine, amphetamines) •…

1.3.1 Hyperacute rejection Hyperacute rejection occurs immediately after transplantation, typically within minutes to hours. It is due to the presence of preformed antibodies in the recipient’s serum which are either directed against donor HLA antigens (referred to as DSAs) or ABO blood group antigens located on the graft endothelium {Chan:2000ui, Howell:2010fg, Overviewoftranspla:2013ty, ImmunologicAspects:2002tn}. Following anastomosis and blood flow into the graft, the antibodies bind to…

Sometimes despite optimal care, some patients become severe developing refractory hypoxemia. In this case extracorporeal membrane oxygenation or ECMO is the last hope. ECMO, a highly invasive procedure similar to a cardiopulmonary bypass machine comes with significant risk and complications, with rates of mortality near 60%.26 ECMO involves a skilled group of caregivers capable of monitoring and managing the patient correctly. Two different methods can be used, veno-atrial which requires a…

During the Body Works experiments the patient performed a number of tasks. The patient performed a task called the Eat Healthy (My Pyramid/Diabetes) where she picked out a number of meals that represented the types of meals that she would eat on any given day. She selected foods like spaghetti and meatballs, a turkey sandwich, hamburger and fries, and a chocolate ice cream bar. After the patient was finished picking through the menu the machine then gave her a total for the amount of calories…

However, ischemia-caused ATN is the main contributor of intrarenal acute renal failure (Mehta et al., 2011). Postischemic ATN may result and cause hypotension, hypoperfusion, and hypoxemia. Consequently, there will be a decline in ATP production and increases in toxic…

complete blockage can cause a heart attack. ACUTE CORONARY SYNDROME (ACS): Acute Coronary Syndrome (ACS) can be defined as a spectrum of clinical conditions from unstable angina to ST-elevation Myocardial infarction (MI) consequent to myocardial ischemia. In vivo imaging techniques applied in humans and the success of fibrinolytic and antithrombotic therapy in ACS established in practice the role of thrombosis in their pathogenesis. A number of micro anatomic mechanisms underlie acute…

All those who are intubated must be extubated! Anaesthesia is a science but learned and practiced as an art. Contrary to its traditional image, functions of modern day anaesthesiologist expands far beyond the boundaries of anaesthetizing and de-anaesthetizing a particular patient. Taking utmost care of the patient and safeguarding the patient from possible untoward events during anaesthesia and surgery is the supreme duty of the anaesthesiologist apart from optimal pain relief to the…

The incidence of atrial fibrillation increases with age which can causes serious problems in older people, leading to stroke and/or heart failure. Risk factors include hypertension, previous ischemic stroke, transient ischemic attack or other thromboembolic event, coronary heart disease, diabetes mellitus, heart failure, and mitral valve disease (Holding et al., 2009). In addition to advanced age, patients that are obese, of the Caucasian race, or have a history of excessive alcohol use are at…