Intravenous immunoglobulin

above 10 ng/mL (6). Gene analysis can be also performed to look for mutations in the ATM gene (2). A karyotype of A-T patients is characterized by t7;14 translocations and leukemic clones (3). Healthcare faculty should also need to look for serum immunoglobulin levels (IgE, IgA, IgG/IgM), and B/T cell levels of the patient. Low levels of these components indicate defects in humoral and cellular immunity. Other tests such as radiosensitivity assay, MRI of cerebellum, chest x-ray can be obtained…

Gisselle Pernett After going in for a routine checkup and expecting to have normal results, America Hernandez was being rushed to a hospital for a condition her doctors knew nothing about. It wasn’t until she was hospitalized that she was diagnosed with idiopathic thrombocytopenic purpura, a rare condition that causes the immune system to mistakenly attack the platelets in her body. This condition prevents the blood in her body from clotting, and when this happens even the smallest cut can…

Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare, neuromuscular junction autoimmune disease. The immune system produces immunoglobulin G antibodies against voltage-gated calcium channels (VGCC) residing on the cell membrane of the presynaptic nerve ending.1,3,5,6 The etiology of LEMS is decreased exocytosis of the neurotransmitter acetylcholine from presynaptic neurons into the neuromuscular junction (NMJ) caused by autoantibodies attacking VGCCs.3,7.10 There are two distinct groups of LEMS…

This article is about the hypothesized neurological disorder. For other uses, see Panda (disambiguation). PANDAS Streptococcus pyogenes 01.jpg Streptococcus pyogenes (stained red), a common group A streptococcal bacterium. PANDAS is hypothesized to be an autoimmune condition in which the body's own antibodies to streptococci attack the basal ganglion cells of the brain, by a concept known as molecular mimicry. Classification and external resources Specialty Neurology ICD-9-CM 279.49 Patient UK…

The Zika Outbreak The Zika virus is an emerging new illness that may have more consequences than originally thought. Ever since an outbreak in Uganda in 1947, the world attempted to fully understand Zika, but even now, the medical community cannot quite comprehend everything about it. As more cases of the virus are being reported, people are attempting to combat and eradicate the illness using old and new methods. If the Zika virus continues to spread, future generations may receive the heavy…

There was not substantiation for neoplastic processes, therefore an oncological diagnosis wasn’t performed. Normal immunologic tests (normal values of immunoglobulin A, M, G, Ag, normal phagocytic activity of neutrophils and nitro-blue tetrazolium test, a sufficient level of circulating immune complexes and negative immunofluorescence assay of Human Immunodeficiency Virus (HIV) ruled out a possible diagnosis…

tissue, any puncture wound that has been in contact with manure or soil, or a serious compound fracture that has been exposed to infection according to the National Health Service. Patients with the types of wounds listed should receive the tetanus immunoglobulin, TIG, as soon as possible as it contains antibodies that kill the bacterium Clostridium tetani. This treatment is injected into the vein to provide an immediate short-term protection against the infection of tetanus. Doctors can also…

The goal of each pharmaceutical company is to develop drug product and get marketing authorization approval. It changes the life of the patients by giving better life. When a company is planning a drug development journey it should have clear thoughts how new product will improve the patient’s life compare to available products in the market or in the pipeline. A Target Product Profile (TPP) is very helpful assistance in recognizing the chosen product characteristics and interactive them to the…

Induction therapy for ANCA-associated renal vasculitis involves the use of high dose intravenous Glucocorticoids and Cyclophosphamide, inducing remission of the disease(1,20). However, this method has a high risk of morbidity and mortality due to infection. Yet this is dependent on patient’s age, duration of the treatment and the dosage of…

Ventricular Septal Defects (VSD) Ball & Bindler (2008) describes this condition as an opening in the ventricular septum, which causes an increase in pulmonary blood flow. VSD is a hole in the wall separating the two lower chambers of the heart (AHA, 2016). The blood is shunted from the left ventricle artery, across the open septum into the pulmonary artery without any impediment (Ball & Bindler, 2008). The opening may cause a higher pressure in the heart or reduced oxygen to the body (AHA, 2016)…