Interleukin

Glucosamine is an amino sugar that is produced naturally in humans to make cartilage, the tissue that cushions the joints. In normal joints, cartilage provides a protective jacket that covers the end of each bone which in return provides a smooth, gliding surface for joint motion and acts as a buffer between the bones. When the surface layer of cartilage between the bone of a joint is worn down you more than likely will be diagnosed with osteoarthritis. Osteoarthritis is also known as…

Results Table 1 showed that oral administration of Diclofenac sodium at 150mg/kg.b.w. resulted in a significant increase in renal tumor necroses factor -α (TNF-α), nitric oxide (NO) and thiobarbaturic acid reactive substances (TBARS) compared to the normal control group (p< 0.01). Rat receiving extract of any of the two doses of cranberry extract used in this study (75 and 150mg/kg.b.w.) showed a significant decrease in renal TNF-α, NO and TBARS compared to the group that received Diclofenac…

bloodstream or when tissue injury occurs, an inflammatory response occurs. The response causes a stimulation of the immune system to produce interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) (Neligan, 2006). These cytokines are the main catalysts of the inflammatory response and cause the release of several agents including, interleukin-8, histamine, kinins, serotonin, selectins, and neutrophils. When the above compounds are activated, local vasodilation…

Ovarian cancer (OC) is the fifth-leading cause of deaths relating to cancer, with less than half of all patients surviving for more than 5 years following diagnosis. It affects women of all ages, most commonly diagnosed after menopause and aged between 55-65 years, 75% of whom are diagnosed at an advanced stage of the disease. Risk factors include age, hormone therapy, and most notably genetic syndromes, such as BRCA1 mutations which are involved in 10% of OC cases. This essay will present the…

The variability of the human gut microbiome and its effect on health Abstract The human gut microbiome consists of a wide range of microbes such as bacteria, fungi and archaea which can be found in the gastrointestinal tract. This gut microbiome can have both beneficial and harmful effects on the host. On one hand, it is involved in processes such as modulation of the immune system and metabolism which are beneficial for the human host. On the other hand, an imbalance in the gut microbiome…

Schizophrenia is a debilitating disease that causes its victim to experience symptoms that include but are not limited to, hearing and seeing things, delusions, disorganized behavior or speech. However, there are many different symptoms for this disease and they vary from person to person. Schizophrenia is all over the world (about 1% of the world to be exact) but it is defined differently from nation to nation (Shon W. Lewis, 1998, pp. 23-24). It also effects men and women almost equally, being…

CRP was identified from patients with acute pneumococcal pneumonia at the Rockefeller Institute for Medical Research (Tillett and Francis, 1930), a name that reflects its reaction with the C-polysaccharide of Pneumococcus. This pentameric protein with MW 118 kDa has five non-covalently bonded and non-glycosylated identical subunits of 206 amino acids each to form a disk-shaped pentagon (Fig. 1). CRP has been proven as an early indicator of infectious or inflammatory conditions as well as a…

One third of our composition of the gut microbiota resembles to our parents composition of microbiota. But after being born, the 2/3rd of our composition of our microbiota is dynamic up until the age of 3. There are several factors that affect the composition of the gut microbiota throughout our lives but it is most effective on newborns. The first factor that affects the composition of the microbiota is how the baby is delivered. (2) Vaginally delivered babies are colonized by vaginal microbes…

Jones. Mr. Jones appeared to be in distressed. He is now using his accessory muscles to breathe, crackles are heard on auscultation and there is decreased air entry in the left and right bases. Chest X ray revealed consolidation on the left lower lobe and atelectasis in the right lower lobe. After a series of investigation in the emergency department, Mr. Jones was commenced on Normal Saline at 125 mls/hr and he was given oxygen via non rebreather mask at 10L/min. He was then transferred…

There are strong pregnancy warnings for patients using isotretinoin. What are the birth defects that may occur as a result of isotretinoin use and how common are they? Introduction: Almost everyone can expect to experience acne to some degree during their lifetime. Acne is characterized by noninflammatory, open or closed comedones and by inflammatory pustules, papules or nodules. It affects mostly the dense skin area with lots of sebaceous follicles such as face, back and upper part of the…