Inhibitor

In the article, “Selective Serotonin Reuptake Inhibitors And Risk of Suicide: A Systematic Review of Observational Studies” is a research about the link between selective serotonin reuptake inhibitor and the suicide rate. Selective serotonin reuptake inhibitor (SSRI) are class of antidepressant drugs on which many debates and research have taken place over the years and yet now there is no definite conclusion. In this peer-reviewed research, not only SSRI drugs were used, but also other antidepressant drugs were used in the experiment to draw a proper conclusion on if there is a possible relationship between antidepressant drugs and the increasing suicide rate. The experiment were carried by combining the results from independent studies which…

Selective serotonin reuptake inhibitors (SSRIs) remain the mainstay pharmacological treatment for OCD. They are fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram and escitalopram. In this case, Mrs P was taking escitalopram. However, in contrast with depression, SSRIs treatment in OCD requires higher dosage and the response time is somehow longer. Usually, patient with depression respond to SSRIs within 2-6 weeks whereas patients with OCD take 10-12 weeks of response time (Dougherty,…

Various structural inhibitors diminish the effectiveness of organizational teamwork. In healthcare, effective team building can increase productivity and tackle ongoing problems. While dealing with issues, a team of collective backgrounds can achieve success for the organization. It may often take multiple interventions for a team to build trust and deliver productive ideas. One important component for leaders to consider are the various inhibitors to a successful team. These conflicts arise…

2.9.2.1. Coagulation Inhibitors Protein C plays crucial role in controlling anticoagulation and is a vitamin K-dependent serine protease (zymogen). Protein S (a vitamin K- dependent glycoprotein) acts as a cofactor for APC (activated protein C) [133]. Protein C and S slow the coagulation cascade with inactivating coagulation factors such as factor Va and VIIIa. Protein C and protein S are division of a feedback control mechanism, in which excess thrombin production causes protein C…

Replication Inhibitors Replication inhibitors interfere with DNA synthesis. There are many of these inhibitors, but they typically work via two main mechanisms. One of these mechanisms involves either disrupting molecules that are needed for DNA polymerization or those needed in order to initiate replication. The other mechanism is by interfering with replication checkpoints that are involved in regulating the replication process. These checkpoints sometimes do this by triggering certain…

Histone Deacetylase Inhibitors. Histone deacetylase (HDAC) inhibitors are responsible for inhibiting histone deacetylase enzymes, which work to remove acetyl groups from histones. The overexpression of HDACs is responsible for many cancers such as prostate, colorectal, breast, lung, liver, and gastric cancer. Currently, four drugs are FDA approved to function as HDAC inhibitors: Vorinostat (2006), Romidepsin (2009), Chidamide (2015), and Panobinostat (2015). Vorinostat is a linear hydroxamic…

α-Glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates specifically α-glucosidase enzymes in the brush border of the small intestine. This inhibits the cleaving of di and oligosaccharides to monosaccharides, such as glucose prior to absorption. This delays the absorption of glucose and alters the release of glucose dependent intestinal hormones. Acrabose, Migltol (10) and Voglibases (11) have been extensively studied for their…

Catalysts and Inhibitors work by providing an alternative reaction pathway for the breaking and remaking of bonds in chemical reactions, changing the speed of the reaction. They are neither consumed in the reaction. Rather, they alter the amount of activation energy required. Different reactions require different catalysts, as well as different reactions require different inhibitors. The reaction energy path controls the speed of the reaction. The molecules follow the path of least resistance,…

its inactive state. It binds to Rab escort protein (REP), which directs it to the RGGT, where the Rab protein is isoprenylated by addition of geranylgeranyl pyrophosphate (GPP) group or farnesyl pyrophosphate (FPP) onto the cysteine. The REP then transports the prenylated Rab protein to its target membrane where guanine exchange factor (GEF) exchanges the GDP to GTP to activate it. The Rab protein can then associate with its effector protein, specific to the Rab type, to carry out functions such…

Since their introduction in 1988, proton pump inhibitors (PPI) have become one of the most prescribed drugs worldwide especially for the treatment of peptic ulcer and gastroesophageal reflux disease (GERD). (1) Proton pump inhibitors (PPIs) effectively suppress gastric acid production by inhibiting the function of H+/K+-ATPase in gastric parietal cells. (2) Also, the indications for esophagogastroduodenoscopy (EGD) have significantly increased, including GERD. These patients usually tend to be…