Infusion

Argatroban Argatroban is a synthetic direct thrombin inhibitor. It binds reversibly to thrombin so it requires to be given as a continuous intravenous infusion. It is metabolized mainly by the liver so it needs dose reduction in liver impairment. Its half-life is moderately extended in renal impairment. The effect of renal impairment on argatroban dosage adjustment is unclear. Some studies which were done on dialysis patients used the same dose in normal renal patients with no additional adverse…

The goal of each pharmaceutical company is to develop drug product and get marketing authorization approval. It changes the life of the patients by giving better life. When a company is planning a drug development journey it should have clear thoughts how new product will improve the patient’s life compare to available products in the market or in the pipeline. A Target Product Profile (TPP) is very helpful assistance in recognizing the chosen product characteristics and interactive them to the…

Than the rate of infusion should be decreased to avoid this side effect. Thrombophlebits may occur with all the three drugs. Final, the tolerability of echinocandins seems to be comparable to that of fluconazole and better than that of amphotericin B.  Flucytosine Flucytosine…

attention to aseptic technique are essential during the insertion of all vascular access devices. Infusion sets and stop clock caps should be changed not more frequently than every 3 days, unless an infusion set is used for the delivery of blood or lipid solutions. Infusion sets and tubing for blood, blood products, or lipid emulsions should be changed within 24 hours of initiating the infusion. Blood infusions should finish within 4 hours of hanging the blood; lipid solutions should be…

Nurses play a major role in preoperative , intra-operative and postoperative pain assessment and management .Pharmacological management is a challenging process to relieve pain. The first choice of drug is a background pain relief, is regular paracetamol, which is safe in the young and in the elderly, is well tolerated, effective in nociceptive and neuropathic pain and available in several dose forms. Regular doses of between 4g daily (four times a day) is recommended for…

After consuming food, it’s advisable that you must brush your teeth. The reason for this is that a colorless, sticky substance which in the end becomes white, called plaque, starts to develop on our teeth, without us perhaps even knowing. If plaque isn’t eliminated continually, it hardens, getting to be the terrible tartar. Thankfully, it’s possible for you to eliminate dental plaque naturally at home. The important is to avoid it before it becomes an issue. At this moment, we’ll have a…

intubation and decreased postoperative opioid requirement (5, 6). We used a caudal block which has been shown to have beneficial impact on respiratory physiology in healthy spontaneously ventilating children under propofol infusion with LMA (7). Additionally, we used propofol infusion, because dystrophic patients who are exposed to volatile anesthetics may develop a malignant hyperthermia-like syndrome or rhabdomyolysis (8). To the best of our knowledge, this is the first report in the existing…

DISCUSSION The aim of this study is to assess the efficacy of infliximab in the treatment of ulcerative colitis and to observe the presence of any side effects to infliximab. Infliximab tends to be used as a third-line therapy in patients with moderate to severe UC or as a rescue therapy [8]. However, experts have proposed that earlier use during less severe disease states (i.e., moderate UC) could benefit many patients [9] [10] [11]. Furthermore, infliximab can potentially attain the new…

Epinephrine should always be available to treat anaphylactic reaction due to antivenom. Antivenom infusion should be started slowly, with the physician at the bedside during the initial period to intervene immediately at the first sign of an acute reaction (which may be heralded by a single hive or mild itching or may present as bronchospasm or acute cardiovascular collapse). The rate of infusion can be increased gradually in the absence of a reaction until the full starting dose has been…

for many years. She had tried several treatments, but nothing she used seemed to work. She constantly felt achy and miserable and was looking for answers. Finally, Caroly's rheumatologist recommended administering a biologic drug via intravenous infusion. When this medication is given periodically, it can alleviate stiffness and pain. It can also reduce joint damage. Carolyn also takes an antimetabolite. This is a drug that affects cell division. It also reduces inflammation. Carolyn gives…