In vivo

1 Introduction Berberine (BBR), an isoquinoline alkaloid (Fig. 1), is isolated from many medicinal herbs, such as Coptidis rhizome (Coptis chinensis Franch.) and Cortex phellodendri (Phellodendron chinense C.K.Schneid.) (1). BBR has been used to treat microbial infection, diarrhea, and other gastrointestinal (GI) diseases due to its antibacterial, antidiarrheal and strong antidotal properties (2, 3). In recent years, much focus has been put on its other potential bioactivities, such as…

techniques that I learned about in the course include: imaginal flooding, in-vivo therapies, dialectical persuasion, paradoxical tasks, and systematic desensitization. I chose the imaginal flooding technique because I would like to learn more about how this technique is executed and how effective it is. A counseling situation that this technique might be effective in is assisting someone suffering from depression. The use of in-vivo therapies stood out to me because I find amazing how a person…

with DNA that codes for Lef-1/Tcf Wnt transcription factors that will work with added beta-catenin, c-Myc, Tap63 and GATA-3. This method can pose problems in vivo, because the recombinant DNA can result in uncontrolled growth; however, reversing the DNA back to is prior state is cannot be done in so many daughter cells. Instead, for in vivo use, human epidermal cells are proliferated in contact with fibroblasts. They can be cultured adjacent to a layer of fibroblasts isolated from the patient…

importance of the SaeR/S TCS in S. aureus pathogenesis by demonstrating its role in regulating the transcription of virulence genes in response to various host stimuli; however, the environmental factors that trigger saeR/S and its impact on virulence in vivo remain incompletely defined (Nygaard et al., 2010; Zurek, Pallister, & Voyich, 2015). We hypothesis that S. aureus frequently encounters the lung environment but maintains an avirulent state by negatively regulating the saeR/S. Upon…

ring to 9-hyroxyrisperidone (9-OH-RIS), mediated by the liver enzyme, CYP2D6 [7]. Risperidone is a second-generation antipsychotic agent widely used in the treatment of schizophrenia. It is converted to the active metabolite, 9-hyroxyrisperidone, in vivo. In fact, the “active…

Diabetic neuropathy is a very common chronic complication of diabetes mellitus that develops in about 50% of people with diabetes . Globally, as well as in India, the number of patients with diabetic neuropathy is rapidly increasing. Despite the widespread occurrence and devastating effects of the disease, complications and pathways involving its origin are still not fully understood, and there is no treatment available to prevent its development, other than the overall control of the diabetic…

N-Vinyl pyrrolidone (NVP) and its copolymers attracting much attention and have been widely investigated for applications in different field due to its low toxicity, biocompatibility and good film forming (Hemalatha et al. 2014; Anasuya; Lee et al. 2007). The amide group in NVP is highly polar, which confirms it’s hydrophilic. NVP has been copolymerized with various monomers because the amide group has high affinity for many large and small molecules that are known to be good hydrogen-bond…

kidney epithelium, muscle cells and many others. Since telomere shortening can trigger cell senescence in vitro, current theory is that telomere shortening represents a dominant cause of tissue dysfunction that characterizes the aging process in vivo; hence, telomere length is increasingly being accepted as a valid biomarker of aging. For that purpose, peripheral blood leukocyte telomere length is a best way to asses systemic telomere length. The rate of telomere shortening with age is…

On October 31, 2017, at 4:00 pm, I attended the Department of Biology Seminar Series hosted by Dr. Richard Gomer that helped in the Biological Sciences Building East, Room 115. The lecturer was Dr. Carolyn Cannon from the Department of Microbial Pathogenesis and Immunology at the College of Medicine TAMHSC. What intrigued me to go to this lecture was the title, “Wolves in Sheep's Clothing: Killing Bacterial Pathogens with Innocuous Compounds. Surprisingly the title did match the content that Dr.…

children were randomly selected for treatment A and followed the ABBABAAB pattern and four children were randomly selected for treatment B and followed the BAABABBA pattern. Treatment A consisted of shaping, modeling, prompting, and stimulus fading and in vivo exposure. Treatment B consisted of a parent-based reward and consequence system for speaking/non-speaking. Each child received two sessions per week (Vechhio, 2007). To measure the treatments integrity, rating scales were given…