Human genome

Ever since scientists uncovered more information about genes, DNA, etc., a lot of scientific advancements linking to the topic have risen like, DNA fingerprinting, gene therapy, and manipulating genes. Lily E. Kay’s Who Wrote the Book of Life: A History of the Genetic Code published in the year 2000, talked about the detailed history of one of the most important events in modern science, the genetic code. Genetic code is the sequence of organic bases on the double strands of DNA. The bases are…

Day in the Life: Elena Flowers Photos of her two, young daughters and their painted handprint artwork decorate the office of Elena Flowers, PhD, RN. She is a mom, but she identifies as a researcher and professor too. “In April, I am volunteering at my daughter’s school for DNA Day to talk about my job,” Flowers said. “I appreciate that my job allows me the scheduling flexibility to do that.” While her job allows for flexibility, it can also cause her to work for several hours on a Friday…

this we had to carry out the following steps: DNA extraction, PCR and gel electrophoresis. I found that my genotype matched my phenotype, showing that I was a PTC taster and my genotype was hetero zygote taster. DNA extraction DNA is removed from human cells for a range of reasons. With a pure sample of DNA you can test for a genetic disease, analyze forensic evidence, or study a gene involved in cancer. DNA extraction is an important part of the process because the DNA first needs to be…

Over the first five months of my M/Phill program I worked on two major projects: SPTLC1 and UNC13a genes. SPTLC1 Project The goal of SPTLC1 project was to show that mutations in SPTLC1 gene are the cause of amyotrophic lateral sclerosis(ALS). The following project was done in three steps: exome sequencing of a trio, exome sequencing of a large ALS cohort and matched control samples, and Sanger sequencing of SPTLC1 gene. The projects began with the discovery of a family that consisted of…

Could our truth be encoded in our genetics? We can now access information about our genomes through genetic testing through companies that analyze, and find errors in, our genome. Genetic testing can help us better understand the current health status of our bodies. It’s vital that we develop an understanding of our internal environments; especially if we seek prosperity for the future without being affected by potential health issues caused by our genetic mutations. Specific diseases (or other…

When analyzing my DNA sequence I did not yield as much of a high quality sequences as others this may have been due to the fact of poor pipetting into the well or kit manufacturing issues. In order to find the changes that occurred in our DNA our reverse edited sequence was placed into James Licks mtHAP engine found at http://dna.jameslick.com/mthap/. Another search engine found on http://www.mitomap.org/foswiki/bin/view/MITOMASTER/WebHome was used to verify if the previous engine was correct,…

replication (102,103). The exogenous agent who can damage the DNA include various types of radiations, such as Ultraviolet radiation, Ionizing radiation or various mutagenic compounds used in many processes (104). It is hypothesized that every single human cell encounters 104 to 106 DNA lesions every day (105). Thus all cells rely on a correct DNA repair system, which can repair the various type of DNA damage and keeps the genomic integrity of DNA intact. In order to maintain the genomic…

Genetically Modified Organisms are a topic of strong debate that sparkles both pros and cons, fuelled largely by a lack of understanding and huge amounts of misinformation that give wrong ideas. My research project is introducing the issues related to this and covering both pros and cons, and my own opinion towards this. •Explain what is involved with this biological issue Genetically modified organisms, also known as a transgenic organism, are living organisms whose genetic material has…

Abstract Tafazzin, encoded by the TAZ gene, is a mitochondrial membrane-associated protein that remodels cardiolipin (CL), an important mitochondrial phospholipid. CL is essential for proper mitochondrial structure and function, ensuring proper functioning of energy production and apoptosis. TAZ mutations are associated with the X-linked metabolic disorder, Barth syndrome (BTHS). BTHS is a lipid metabolic disorder that affects mitochondria that is often fatal in infancy and early childhood, due…

Lmna Mutations and HGPS Collins and his team of researchers decided to screen 23 affected individuals for mutations of the Lmna gene. They chose the Lmna gene due to its involvement in a wide spectrum of heritable disorders including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, and Charcot-Marie-Tooth disease (“Lmna”). The decision to screen the Lmna gene definitely paid off, as three different mutations were discovered. The mutations…