HotSpot

abolishing its transactivation function because mutant p53 cannot activate p21WAF1/CIP1, the cell cycle can proceed unabated. It is Exon 5-8 which are very prone to mutations & codon 157 is commonly known as mutational hotspot in lung Cancers, besides that codon 248 & 273 mutations are hotspot positions in other cancers for example, colon and liver cancer, suggesting the heterogeneity among TP53 mutations. One interesting thing is these codons contain CpG islands, and the presence of 5-methyl…

The examples demonstrated in the lecture has impressed me a lot. For instance, the puppy plaza in Canada. Poppy plaza is a public space that designed to honor people who served to protect Canada’s freedom and security during wartime. Although I have never been there, I can feel the space evokes the sense of connection with distant places. The narratives and topography are concise that portraying different voices and make me feel stunning. I realize there is a question that we should think – How…

My Lakeshore My Home (MLMH), produced by Sirius Theatrical is one of these plays. Performed in partnership with the City of Toronto and the Etobicoke-wide year long festival Cultural Hotspots, it is a festival in itself which celebrates the diversity of the people who call the Lakeshore their home. Cultural Hotspots is a City of Toronto initiative which aims to showcase the heritage, creativity and culture of a specific community each year. I was fortunate…

Our Story Our story begins in 1986. Jim Mundt, a McCall smokejumper, spent countless hours that season on hands and knees crawling through the ashes on mostly cold lightning fires to ensure that they were completely extinguished: a technique known as cold trailing. Discouraged by the tedious task, Jim had the idea of a heat sensor at the tip of a 4 foot pole that would make the discomfort of bare handed cold trailing a thing of the past. The following season, Jim left the jumpers and began…

California’s Mediterranean climate is at risk, along with a few precious plants that only grow in the Golden State. Riordan and Rundel (2014) state, California contains “nearly 20% of the world’s vascular plant species, these regions are global biodiversity hotspots” and are a major part of reversing air pollution. Due to a higher demand in agricultural products, farmers and companies have expanded and opened up more land to develop and farm. Again Riordan and Rundel add that agricultural land…

At first, the Aral sea was a very plentiful hotspot for boating and fishing. Throughout the years, the sea has been decreased in size by 90 percent leaving a much smaller body of water very high in salinity. Due to the sudden increase of salinity, the fish and plant population has decreased greatly. This means that the large fishing industry was gone and the humans were impacted immensely. The big question was, “How did it happen?” this is easily answered by “the impact of humans. Without…

particular times. In 1988, officers of the Minneapolis Police Department began a yearlong experiment to test the effect of police patrol presence on crime. In the first experimental study of hot spots policing, directed patrol at 55 randomly selected hotspots in Minneapolis were evaluated. Officers concentrated patrols on the experimental hot spots during high risk times of the day and night, without answering calls for service (Woods,…

Australia’s 10 Best Camping Hotspots The awe-inspiring beauty of Australia can be difficult to tackle. When there are so many opportunities surrounding you, figuring out which parts of this iconic beauty you experience can be tough. While sometimes the best option might be to just jump on your car and drive away, exploring the tried-and-tested locations can add ease to your camping experience. If you are looking to back your bags, these are the best camping hotspots Australia has on offer. 1.…

Introduction Congenital anomaly is a serious global public health problem, because it is a major cause of child mortality and morbidity worldwide. Congenital anomaly causes lifelong disability and considerable impacts on the health care system. In 2015, congenital anomaly is responsible for nearly 276 000 neonatal deaths around the world; 95 % of the deaths come from low-middle income countries (1) (2). Prevalence and pattern of congenital anomalies have been reported in developed countries.…

writing for the Boxer Roundup since sophomore year and have been an editor since last summer. By writing for and editing the Boxer Roundup I aim to highlight the positives that take place in my city and to help erase the view of the city as just a hotspot for crime and poverty. As a journalist, I hope to be able to bring to light the stories of those that may be overlooked and provide a factual account of events. One quality I feel I can bring to the Journalism Department…