Homology

Depression is a brain disorder which generate major disability. Its etiology and molecular mechanism is not fully understood. It is a leading cause of disability globally, with lifetime prevalence as high as 20% (Kessler et al., 2005). Depression is multifactorial disorders that differ in symptomology and most possibly in etiology. There are various symptoms of depression include depressed mood, mood swing, loss of pleasure activities (anhedonia), inability to concentrate, lack of energy,…

1. Introduction Lernaea infection is a major disease problem encountered in carp culture in the Indian subcontinent and has been reported from Indian major carps Catla (Catla catla), Rohu (Labeo rohita), Mrigal (Cirrhinus mrigala) , exotic carps silver carp (Hypophthalmichthys molitrix), grass carp (Ctenopharyngodon idella) and indigenous carps Labeo fimbriatus (Nandeesha et al., 1984, 1985; Tamuli and Shanbhouge, 1996; Zafar et al., 2001). The three Indian Major Carps viz., Catla, Rohu and…

ABSTRACT N-Myristoyltransferase (NMT) is an attractive target for the development of novel antimalarial drugs. In this paper, we report a hologram quantitative structure-activity relationship (HQSAR), a comparative molecular field analysis (CoMFA), and a comparative molecular similarity indices analysis (CoMSIA) studies on a series of benzo[b]thiophene-containing selective inhibitors of plasmodial NMT. Two QSAR models were constructed, one for Plasmodium falciparum NMT and another for Homo…

1. Introduction: Squamous cell carcinoma of the head and neck (SCCHN) can be ranked as the sixth leading cancer by incidence worldwide (1,2). Every year, there are more than 550,000 patients diagnosed with head and neck cancers worldwide and around 300,000 related deaths (3). Squamous cell carcinomas represent 90% of cases and mostly arise from the epithelial lining of the oral cavity, oropharynx, larynx, and hypopharynx. SCCHN can be divided into three stages: early stage (I/II), locally…