Hemostasis

4. Plasminogen Activator Inhibitor-1 (PAI-1) PAI-1 is used to evaluate the risk of thrombosis. It is a serine protease inhibitor (serpin), therefore it is also known as serpin E1. Human SERPINE1 gene encodes for PAI-1. PAI-1 inhibits Fibrinolysis through the inhibition of the serine proteases, Tissue plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which activate plasminogen. So any increase in PAI-1 decreases fibrinolysis consequently increasing the risk of…

individual’s hemostatic profiles under certain conditions and particular drugs will lead to a better understanding of bleeding risk ad clinical clotting prediction. Unlike other complex bench-top tests, it can reproduce the physiology of in vivo hemostasis and thrombosis. FlowMAP measurements do not lack of freedom degrees to decode thrombotic states as it happens in single measurements. Its variability reflects the hemostatic state when reacting to controlled drugs.…

Theoretical/Conceptual Paradigm The study is based on the premise that various preparations of platelet concentrate such as PRF and CGF may be regarded as healing biomaterials since they contain all the necessary components permitting optimal wound healing following surgical procedures. Components such as growth factors and pro-inflammatory cytokines have been reported to work in unison for the achievement of wound healing in various medical and surgical cases. As such this can be a…

Laughter. It is universal and it is complex. There are many theories associated with laughing all trying to answer whether laughter an acquired social construct or is it an innate behavior that has been engineered from our biology? A drive is an “excitatory state produced by a homeostatic disturbance” (melon, 1996), an inherent demand that carries the potential of activating and forcing the behavior of the individual. The drive theory assumes that individual is innately programmed…

In recent year’s nanorobotics have emerged at the forefront of medical advancement. Although nanorobotics is largely still in the research and development stage, there are current applications for them. Nanorobotics has shown promise in the treatment of diabetes, cancer, surgical procedures and a multitude of other ailments. In 1986, K. Eric Drexler introduced the idea of injecting the small robots into the human body (Manjunath, A., 2014). Imagine a world where surgery in non-invasive and lasts…

The fibroblasts proliferate and synthesize and secrete proteins such as types of collagen during the phase of healing Hemostasis and degeneration. The function of these proteins is to reconstruct the extracellular matrix and provide a scaffolding- like framework for the developing endothelial and parenchymal cell. It is a t the point that this proliferation and migrations…

Blood, in all living things, is a very complex substance that scientists are learning new things about every day. Blood is characterized as a thick substance that has variations in color depending on how much oxygen is present in the blood. If a person’s blood contains ample amounts of oxygen it will be a bright red color and if it contains a low level of oxygen the color will be a dark red. Blood composition is forever varying due to the addition and removal of all sorts of substances in the…

factors to osmotic balance, and requires to maintain constant osmotic regulation (Manuguid 1. et al. 2). PH level is important to measure how many proton has secreted or how much bicarbonate has been secreted or reabsorbed. It is very important that hemostasis be maintained to balance the internal conditions to be stable constantly, and within the normal range because it is essential for the survival. The kidneys…

Blood is the only liquid in the body that is classified as connective tissue. Its function is to transport oxygen, metabolic wastes such as carbon dioxide and nitrogenous waste from the kidneys. Regulation of the body’s pH, body temperature, and maintenance of the liquid volume in the circulatory system. Lastly, protection by way of Leukocyte activation and preventing blood loss by way of the platelets in the blood. Blood is composed of 55% plasma (water, salts, plasma proteins, and other…

uterine leiomyoma is abnormal uterine bleeding. In published series of myomectomies, 30% of women suffered from menorrhagia. The mechanism of myoma-associated menorrhagia is unknown. Vascular defects, submucous tumours, and impaired endometrial hemostasis have been offered as possible explanations[5]. But some other times they have been associated with a number of clinical issues including abnormal uterine bleeding (AUB) especially heavy menstrual bleeding (HMB), infertility, recurrent pregnancy…