Hemoglobin

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    Understanding oxygen supply and demand while working in the health care field is essential. The tissue cell mitochondria need to have adequate oxygen for metabolic consumption and ATP production. There are limited means of oxygen storage in the tissues; as such a continuous supply of oxygen is required. The respiratory and cardiovascular systems work together to make sure oxygen is delivered throughout the body, and that these continuous requirements are met. Exploring the main role of the…

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    inherited disease that is passed from the parents to the child. Both parents that carry the sickle trait or gene will pass the hemoglobin S gene to the child. There are six different forms of sickle cell disease type SS, SC, SB, SD, and SE. The more common form is Hemoglobin SS, which is the more severe form of sickle cell. In most cases children are born with Hemoglobin SS Sickle Cell Disease, meaning the child red blood cells will be sickle shaped and carry less oxygen to the organs. Normal…

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    early childhood (nih.gov). Sickle Cell Disease is a disorder in which the body produces sickle, or “crescent” shaped, blood cells instead of disc-shaped cells. These crescent shaped blood cells are caused by an abnormal sickle shaped hemoglobin molecule called hemoglobin S. A normal RBC is flexible, biconcave in shape, and passes freely within blood vessels. On the contrary, sickle-shaped cells are stiff, sticky and are more prone to blocking blood vessels and sticking to each other. The…

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    Sickle Cell Anemia (SCA)

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    in an abnormal formation of hemoglobin called hemoglobin S. SCA is an autosomal recessive disease, and the individual can inherit the hemoglobin S gene from both parents. Sometimes, an individual can inherit this gene from one parent and have a normal hemoglobin gene from other parents, and are called sickle cell trait. Individuals with sickle cell trait are often asymptomatic but can transmit the mutation to their children. SCA is characterized by defective hemoglobin synthesis that cause…

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    Pernicious anemia is also known as Biermer’s disease and Addisonian anemia. The first clinical description of pernicious anemia, which is one of the known causes of megaloblastic anemia, has been attributed to Tomas Addison in 1849. One way pernicious can develop is the loss of gastric parietal cells, which are responsible for the secretion of intrinsic factor, a protein necessary for absorption of vitamin B12 in the ileum. Vitamin B12 helps the body make healthy red blood cells and helps keep…

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    In other words, anemia may be stimulated by malnutrition, family history of anemia, alcoholism, strict vegan diet, intestinal disorders that affect nutrient absorption of the body, exposure to toxic chemicals, anemia in women during childbearing years, race, and chronic diseases. Signs and Symptoms Fatigue and weakness are the signs of mild anemia. The other signs include pasty or sallow complexion or no color in the palms, gums, nails beds, and lining of eyelids. People who are weak, get…

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    Sickle Cell Anemia Report

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    evident in the patients who are heterozygous for the Hemoglobin S allele. The signs and symptoms that are suggestive of sickle cell anemia include acute fever, relative hypertension, jaundice, ulcers, increase in respirations in acute chest syndromes, cough and hyperactive precordium. The patients may also experience joint pains…

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    opportunity to attach as well. As the groups of attachments move throughout the body to warm themselves when in the cold scenarios, the antibodies destroy the red blood cells. As the cells are destroyed, the part of red blood cells that carries oxygen, hemoglobin, is released into the blood and passed in the urine. (Medline) Characterized by the premature destruction of healthy red blood cells by autoantibodies, Paroxysmal cold hemoglobinuria is a rare type of anemia. Thus, PCH belongs…

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    microparticles derived from sickle cells deliver heme to the vascular endothelial cells causing oxidative damage. Sickle Cell Disease (SCD) is an inherited blood disorder caused by a single base mutation in the DNA of affected patients, producing abnormal hemoglobin molecules. In SCD, red blood cells (RBCs) that carry oxygen lose their flexibility and typical round shape, and become rigid with a distinctive “sickle” shape that make their passage through blood vessels more difficult. Millions…

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    anemia. The disease is autosomal recessive, meaning that if both parents are unknowing carriers of thalassemia, there is a one in four chance of their children having the disease. Patients who have thalassemia cannot produce the normal amount of hemoglobin, which results in anemia, and the…

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