in an abnormal formation of hemoglobin called hemoglobin S. SCA is an autosomal recessive disease, and the individual can inherit the hemoglobin S gene from both parents. Sometimes, an individual can inherit this gene from one parent and have a normal hemoglobin gene from other parents, and are called sickle cell trait. Individuals with sickle cell trait are often asymptomatic but can transmit the mutation to their children. SCA is characterized by defective hemoglobin synthesis that cause…
Sickle Cell Disease is a collection of inherited disorders in which the red blood cells lack hemoglobin. Hemoglobin is an essential protein to the body that assists in the color of the blood cells, as well as allowing oxygen to be carried all over the body (What is Sickle Cell Disease 2016). Sickle Cell Disease first arose in West Africa, affecting hundreds of people. The disease was thought to only affect the people of that area, but it quickly became a widespread disease. Ten to thirty percent…
: Sickle cells pallor is a hereditary issue which causes the declaration of deficient hemoglobin coming about unpredictably formed red platelet, know as “sickle cells”. these sickle cells cause issues in the body frequently blocking blood stream and creating difficult assaults and here and there stroke. Sickle cells have distinctive organic chemistry than typical red platelets and are controlled by numerous free radical procedures. This paper will audit the infection state and examine a few…
abundant supply of red blood cells and a higher concentration of hemoglobin inside their blood which allows for a larger amount of oxygen to be stored in the blood for their deep dive. There are some features about the blood for orcas which enables their ability to dive for more than 15 minutes. Orcas store the oxygen molecules within their bodies and transport these oxygen molecule around their body in a protein called hemoglobin. Hemoglobin is what…
According to “Essentials of Pathophysiology” by Carol Porth, “sickle cell disease is an inherited disorder in which abnormal hemoglobin (hemoglobin S [HbS]) leads to chronic hemolytic anemia, pain, and organ failure”. The recessive gene is inherited and appears as the sickle cell trait if heterozygous or sickle cell disease if homozygous with two HbS genes. The amount of hemoglobin that is affected by the gene depends on if they are heterozygous or homozygous, and therefore affects the gravity…
a protein called Hemoglobin. (1, 7) Hemoglobin is responsible for transporting oxygen from the lungs to the various parts of the body like liver, muscle etc. There are four protein subunits or parts which are two subunits of alpha globin and two subunits of beta globin. (10) The mutation happens in the beta globin called Hemoglobin beta globin or HBB gene. (3) When this occur it produces a hemoglobin variant called Hemoglobin S. (3) Hemoglobin A accounts for 95 - 98 % Hemoglobin and it is the…
In other words, anemia may be stimulated by malnutrition, family history of anemia, alcoholism, strict vegan diet, intestinal disorders that affect nutrient absorption of the body, exposure to toxic chemicals, anemia in women during childbearing years, race, and chronic diseases. Signs and Symptoms Fatigue and weakness are the signs of mild anemia. The other signs include pasty or sallow complexion or no color in the palms, gums, nails beds, and lining of eyelids. People who are weak, get…
Sickle cell anemia is an inherited form of anemia where an individual has either a lack of red blood cell or dysfunctional blood cell, resulting in a lack of oxygen and nutrients to the cells. Normally, a red blood cell would be round, flexible, and flat in the center to allow easy passage in the blood vessels. However, the individual with sickle cell anemia will have cells that are rigid, sticky, and shaped like a crescent or sickle which is where the name comes from. Because of its unique…
level of hemoglobin (Porth, 2011). Hemoglobin, or HGB, is a protein in red blood cells that carries oxygen to organs and tissues throughout the body. Hematocrit, or HCT, is the volume of cells in 100 mL of blood (Porth, 2011). HGB and HCT levels can indicate the severity of the anemia. Mean corpuscular volume, or MCV, tells us the average size of the red blood cells. In this patient’s case, her MCV value indicates microcytic anemia as the level is lower than normal. Mean corpuscular hemoglobin…
Anemias are one of the most common types of blood disorders in the world and can be generally classified as a decreased amount of red blood cells/hemoglobin contained in the blood stream.2 There is more than one type of anemia and they can be classified into Microcytic, Normocytic, and Macrocytic Anemias. Microcytic is usually caused by a deficit of iron in the blood, Normocytic could be due to hemolysis or acute blood loss, and Macrocytic is caused by B12 or Folate deficiency.1,2 Although these…