Heme

Unlike its related holoprotien, myoglobin, Apomyoglobin lacks a heme group within the molecule. This allows the kinetics of refolding to be unimolecular. (Jennings and Wright 1993) In this study, differences in the refolding of proteins with a history of beta sheet will be compared to proteins with a history of alpha…

Introduction Malaria is a lethal disease caused by the Plasmodium species that are transmitted to people through bites of infected female Anopheles mosquitoes.1 There are 5 known Plasmodium species and among these, the P. falciparum is the most dangerous and deadly.1 According to the latest studies, there are approximately 198 million cases of malaria in 2013 and an estimated 584 000 deaths.2 However, Malaria mortality rates have decreased by 54% in the WHO African Region and nearly 47% globally…

Name of disease Sickle Cell Disease Location 11p15.4 – chromosome 11, on short arm of chromosome, region 1, band 5, sub-band 4 Gene/locus HBB – haemoglobin subunit beta HTML reference Stumpf, A.M. (2013). Sickle cell disease Available form: http://www.omim.org/entry/603903?search=Sickle%20Cell%20Disease&highlight=cell%20sickle%20disease Frequency More than 230 000 children with sickle cell disease are born in Africa every year, which makes about 80% of the global total. In Europe estimated…

Gary L. Francione once stated, “Veganism is not about giving anything up or losing anything; it is about gaining the peace within yourself that comes from embracing nonviolence and refusing to participate in the exploitation of the vulnerable.” Veganism isn’t only a physical change, but it’s also a mental one in which an individual is able to find their inner peace by adopting a non-violent lifestyle. Veganism is defined as a lifestyle in which an individual strives to eliminate all uses of…

to determine the existence of blood evidence. Other tests include enzymatic assays such as the Kastle-Meyer test that will turn evidence pink, Leucomalachite will turn green in the presence of hemoglobin in blood. Finally, other techniques such as Heme Select, HemaTrace, or ABA card may be utilized based on personal or department preference (Virkler & Lednev, (2009) Laboratory testing to…

Macbeth is one of Shakespeare’s well-renowned plays that centralizes on a king’s struggle with guilt and, ultimately, the road to his demise. Although Macbeth was known for being a man of bravery and honor, Shakespeare utilized a plethora of literary devices to showcase that his ambition had overcome his state of mind. In Macbeth, Shakespeare used strong dynamic characters, significant motifs, and powerful soliloquies to develop the theme that the ultimate desire for power has the capability to…

The iron content in meat is presented as Heme (a form which is absorbed easily into our body). It is also one of the best sources of vitamin B12. Lean meat without skin is the best option if you are a meat lover. It cuts down fat and supplies you with a high amount of protein, iron, B12 and zinc…

presents in this cyclic organic molecules. Azole drugs target the key enzyme i.e. the lanosterol 14-alpha demethylase, encoded by ERG11 gene. This inhibition occurs through the binding of the free nitrogen atom of the azole ring to the iron atom of the heme group of the enzyme. That leads to the synthesis of toxic compounds, which are unable to successfully replace ergosterol. In 1958, scientific community consider azoles as potential antifungal agents but it was first synthesized in 1944 by…

Enzymes are biological catalysts that speed up the various chemical reactions that happen inside our cells. For the enzymes to function well, they need to be in an environment with a specific set of conditions, other than that it will lead to the denaturation of the enzyme or will render it completely inactive. There are a lot of factors that impact enzyme activities, but in this experiment we examined the effects of 4 different factors which are temperature, Ph level, addition of the inhibitor…

anaemia describes a hereditary autosomal recessive disorder that affects a protein found in red blood cells (erythrocytes) called haemoglobin. Erythrocytes contain about 280 million haemoglobin molecules that are composed of globulin protein and a heme molecule that binds to iron. Haemoglobin allows respiration of oxygen and exchange of carbon dioxide in blood, essential for all body systems. This disorder, determined at contraception, results in 100% of blood cells becoming sickle shaped, thus…