Heme

many prescribed medications for the treatment of acute intermittent porphyria attacks. Hemin is administered to avoid the progression of generalized pain to a neurological crisis. Because delta-aminolevulinic acid, the first step in heme synthesis, is regulated by a heme feedback mechanism, it was determined that acute porphyrias represent a deficiency in hepatocytes (Bissell & Wang, 2015). Hemin helps reduce 5’-aminolevulinate synthase-1 activity allowing the liver to reduce production of…

in veganism. To begin, the explanation on how increased heme, the iron containing compound that gives meat its red color, increases the risk of cancer is very true. The greater the amount of red meat one eats, as opposed to fish meat or white meat, such as chicken, does in fact increase the heme in the gut which overall causes several problems in the digestive tract; although the chlorophyll in plants does override this abundance of this heme, the author did not specifically state how much of…

oxygen and water. Catalase is a tetramer, composed of four monomers wrapped into a dumbbell shape (Nguyen). Each monomer has a heme molecule, a part indispensable to the decomposition of hydrogen peroxide. The heme molecule is responsible for binding oxygen. It is disc like in shape and contains an iron atom at their center. In the decomposition of hydrogen peroxide the heme molecule attaches one oxygen atom to its iron atom, the rest of the previously H2O2 molecule is released as H2O (Goodsell,…

A vegetarian diet is one lacking red meat, poultry and seafood. Whether or not vegetarianism is good for one’s health tends to be a controversial topic, as meat contains more essential nutrients than vegetables. Meat provides a higher-quality source of protein than vegetables because meat is packed with amino acids that vegetables do not supply. The type of iron in meat also absorbs better than vegetables which contributes to low iron levels in vegetarians. Due to these facts many believe that…

has to main forms; the heme iron that is found in the animal sources, particularly red meet, and it is well absorbed. The other form is the non-heme iron that is available in the plant sources, and it is less well absorbed. People who depend in the vegetarian food are at high risk of iron deficiency anemia. However, Amanda can overcomes this obstacle by consuming sufficient amount of vegetarian foods that rich in iron, also consuming small doses of vitamin C with the non-heme iron increasing the…

conformation, the iron molecule is non-planar in relation to the remaining part of the heme group. This non-planar relationship is caused the interaction between the iron molecule and the histidine side chain. However, when the iron binds to oxygen, it changes it position relative to the remaining heme group. This change the position of the iron molecule results in the molecule being planar with the remaining part of the heme group. Also, while changing its position, the iron molecule pulls the…

Proteins are complex molecules that serve a variety of functions within the body. Proteins are made up of subunits called amino acids. There are several different types of amino acids such as lysine, aspartic acid, and histidine. Each type of amino acids have their own specific group called R-groups attached to them, this causes them to behave chemically different. The group on the amino acid histidine cause the amino acid to be basic; this feature of histidine makes it have a specific purpose…

The drug contains a 1,2,4-triazole ring which allows the triazole nitrogen (N-4) of anastrozole to coordinate with a heme iron on the active site of aromatase, this interaction is the primary interaction between anastrozole and the active site of aromatase [6]. Another interaction between the drug and aromatase is hydrogen bonding; this occurs between the triazole nitrogen…

deoxygenated, the protein takes on the R (relaxed) state (Hudon-Miller, 2012b). Another difference arises when oxygen binds to the hemoglobin, resulting in a change in the shape of the protein. In the deoxygenated state, the heme group forms a domed shape; and in the oxygenated state, the heme group takes on a planar shape (Hudon-Miller, 2012b). A2) The relationship between pH and the ability of hemoglobin to bind and release oxygen is referred to as the Bohr Effect. The blood’s pH level is…

Introduction: Enzymes play a major role in biological systems to catalyze and control different reactions. The study of enzymes’ behaviors toward substrates and products is significant to understand various enzyme catalyzed reactions in living organisms. One of the most important enzymatic group is cytochrome P450 (CYP450) which contribute to the metabolism of many endogenous as well as exogenous substances such as drugs. Although there are several subtypes of CYP450 family, CYP450 1A1 is going…