Elucidating the role of Heat shock proteins in poly glutamine (Poly Q) model in Dictyostelium discoideum . Introduction : Expansion of CAG trinucleotide repeats encoding poly glutamine (poly Q) tract in other wise unrelated proteins are responsible to atleast nine diseases . These diseases include Huntington’s disease (HD), spinobulbar muscular atrophy, dentatorubral pallidoluysian atrophy, and spinocerebellar ataxia (SCA) types 1, 2, 3, 6, 7, and 17.(1) Clinical features include ataxia and other movement disorders, loss of cognitive ability, and psychiatric disabilities(2). A characteristic feature of polyQ diseases is the formation of insoluble, granular, and fibrous deposits in affected neurons termed neuronal inclusions, which have…
Immunoprecipitation and Sequencing (ChIP-seq) of Heat Shock Factor (HSF) Temporal Binding Sites during the Critical Period of 8-12 Hr After Egg Lay (AEL) in Drosophila melanogaster Embryogenesis Background Heat Shock Response was discovered by the Italian scientist Ferrucio Ritossa, when he saw puffs in the Drosophila polytene chromosome on inducing them with heat. It was later discovered that this Heat Shock Response was regulated by a transcription factor called Heat Shock Factor (HSF). The…
Before the start of the experiment a Slight shock of 45V is administered to the participant in order to show him what the Learner will be experiencing and to further portray the experiment as authentic (Milgram, 1963). However, the participant is not aware that this will be the only real shock in the experiment. The confederate will not be shocked because he is an actor in the situation (Milgram, 1963). He does act as if being shocked, however. In the Voice Feedback condition the Learner starts…
Our data cover sixteen major industrial sectors from nine countries in the Trans-Pacific region. We apply a factor-augmented vector autoregression (FAVAR) approach (Bernanke, Boivin, and Eliasz, 2005) to reduce the dimension of our data and to simulate the transmission of shocks from the Trans-Pacific region to the US. FAVAR has two advantages compared with traditional VAR. First, it can incorporate a broader set of information related to the unknown transmission mechanism by utilizing…
memories erased, but when I would try to think about how our memory works, I always felt as if I was in the dark about it. It is all a bunch of neurologically connected pieces of protein, in less than a cube foot of space. The movies I watched were science fiction, but erasing memory is actually possible now. When I started to ponder on all this it left me wondering if erasing memories is indeed ethical. Even if our memory is just a bunch of neurological connections of proteins,…
of a woman who rejoiced when a terribly tragic event happened to her husband. This story starts in 1894 when women had no power. The woman’s name was Mrs. Mallard, and she was married to Brently Mallard. She had a heart disease and any seriously shocking moments could trigger a fatal heart attack. Mrs. Mallard is an unsympathetic person based on her desire to become a widow, the perceived joy and freedom of her husband’s death, and the shock she faces when she realizes her husband is still…
In this article “The Peril of Obedience” Stanley Milgram conducted a series of experiments to determine if people would choose to follow authority or obey their morals. In this series of experiments the experimenter Stanley Milgram found a few contributors to test out his theory. Before he started his experiment he had to pick a teacher and a student, who each got a piece of paper to decide which one is going to give the shocks and which one was going to take the shocks. The learner was strapped…
and internal attribution. Occurrences of learned helplessness take place in individuals who have this idea in their mind that none of their actions are within their control due to explicit punishment dealt by a guardian or person in a position of power or whomever, the irony being that guardian 's actions is actually out of the victims control. They believe in failure and motivation severely lacks as uncontrollable stress builds up. The most famous experiment which outlines learned…
It was October 9th, 2013, the day that I and my family moving to the United States from Vietnam and started a new life here. I heard and learned many things about this country before but I was astonished experiencing the country myself. As soon as I discovered there was nothing like I expected, I was anxious and homesick. I wondered how long it would take me to adapt to this new culture and the people. Only a couple months passed, but I already experienced several culture shocks such as…
willing to provide electrical shocks to another person, the experiment tested how far down the severity of shocks the subject would administer to the victim. The question is would being in the position of control and having a feeling as if the subject cannot leave, makes shocking another person justifiable? To begin the experiment, a total of 40 male subjects all ranging within age, education levels, and different races participated in what they thought was a “Study of memory and learning at…