The success of JLS and the Wanted, X-Factor contestants One Direction was the next music group to help revive the boy bands. The group was formed by Niall Horan from Mullingar, Ireland; Zayn Malik from Bradford; Harry Styles from Cheshire; Louis Tomlinson from Doncaster, amd Liam Payne from Wolverhampton ( he had reached the judge's house stages of The X-Factor at 14 years old back in 2008). Each originally entered 2010's series of The X Factor as individuals. But a guest judge Nicole…
wide variation in lower and upper registers for each member is what makes One Direction so successful. Simon Cowell was able to find five voices that each complimented each other uniquely to create complex harmonies that most bands can’t achieve. Because of this, the band has received 281 award nominations in its 5 years, and has won 169 of them. In comparison, 5 Seconds of Summer is a pop-punk band meaning not only does each member play an instrument, there is also a designated lead singer.…
Hemophilia is a genetic disease that causes an affected person to severely bleed if cut. Lucky for hemophilia patients, gene therapy is an option. Gene therapy is a form of therapy during which selected healthy genes are transferred to an affected person’s cells. Not only is gene therapy a breakthrough in genetic engineering, but it can effectively cure genetic disorders such as cystic fibrosis and SCID and some acquired diseases like cancer. Gene therapy is carried out by packing a section of…
that can cause severe bleeding both internally and externally due to having little to no clotting factor. In rare cases, hemophilia can occur in females or even be obtained. Hemophilia exists in two forms – hemophilia A and hemophilia B. Hemophilia A and B are caused by a defect in the genes F8 and F9, respectively. The F8 gene is responsible for making a specific protein called coagulation factor VIII, and the F9 gene for the making of a related protein, coagulation IX. These proteins…
Hemophilia Hemophilia is a bleeding disorder in which blood doesn’t clot normally and results in excessive bleeding. The Jews were the first to recognize hemophilia and was described in the Talmud, which is a collection of Jewish writings, and stated that if two brothers had died after getting circumcised the next male baby from that family didn’t have to go through the procedure. Years later in 1803 a physician named Dr. John Conrad Otto in Philadelphia discovered that the disease was…
curtailed by the drug. MMPs are endopeptidases that degrade proteins of the ECM, and TIMP are their inhibitors. As expected, treatment enhanced the expression of pro-MMP-2 protein and repressed the expression of the TIMP-2 protein. Transforming growth factor-beta (TGF-beta) is a stimulator of collagen production and upregulates collagens in IPF. Nintedanib inhibited TGF-beta-induced secretion of collagens. Through these mechanisms, nintedanib promotes anti-fibrosis and slows the process of the…
Physical education curriculum provides an indispensable opportunity in the establishment of physical literacy, however the aim of PL is to move beyond specific proficiency in specific activities to inclusiveness of all abilities and focuses on competencies in a variety of movements and environments. The internationally accepted definition of PL is “the motivation, confidence, physical competence, knowledge and understanding to value and take responsibility for engagement in physical activities…
Introduction The predominant disease that mutant FGFR3 (fibroblast growth factor receptor 3) gene causes is Achondroplasia. Furthermore, Achondroplasia means the absence of chondrocyte formation in bones. Additionally, the transformation of chondrocytes into bone cells is prevalent in the limbs as well as the facial bones of humans (1). Therefore, the predominant symptom of Achondroplasia is bone growth retardation and is found in the limbs as well as facial bones. The majority of people…
The topic of intelligence can be described as one of the most controversial subjects in psychology, this is because a single definition of what intelligence is can never be agreed upon (Kleinman, 2012). Psychologists like Charles Spearman believe it to be a single ability whereas Howard Gardener believes intelligence is more than just one ability. Similarly, the concept of creativity is very hard to define as Amabile, 1996 (cited in Maley & Bolitho, 2015) states, ‘a clear and sufficiently…
(1999) argued that intelligence is not identical to what test measures and, therefore, ‘g’ factor is rather a subjective measure and…