Haemophilia

Haemophilia is a hereditary bleeding disorder that impairs the body’s ability to coagulate or clot blood; it is caused by a deficiency or absence of a specific coagulation factor, usually factor VIII (FVIII) or factor IX (FIX). People with haemophilia will experience longer bleeding after an injury, easy bruising, and spontaneous internal bleeding. As of now, there only on-demand or instantaneous treatments consists of concentrate infusions of the missing factor and aims to improve a patient’s quality of life (Coppolo at al. 2010). However, there have also been recent studies on utilizing gene and cell therapies as forms of treatment for this disorder, and the results have been highly satisfactory. One kind of cell therapy, using induced pluripotent…

It is a recessive condition on the chromosome X, so the probability of males inheriting the disease is higher than in females due to the presence of only 1 X chromosome. For females however since they have two X chromosomes, inheriting only 1 faulty X makes them carriers. To have the disease, both the X chromosomes should be faulty. Around 1 in 30,000 people are found to have Haemophilia A. Blood clotting requires certain types of clotting factors. Haemophilia patients however lack the clotting…

with hemophilia bleed for a longer time than others after an injury. Hemophilia commonly is of two types –A and B (uncommon is haemophilia C). There are various clotting factors in blood which are required for clotting of blood in the event of an injury. Deficiency of certain clotting factors can impair the clotting mechanism and increase the bleeding time. Hemophilia A is deficiency of clotting Factor VIII in blood. Hemophilia B is deficiency ofclotting factor IX in blood. Both haemophilia A…

Hemophilia is a bleeding disorder that slows down the blood clotting process because of insufficient blood-clotting proteins. People who have hemophilia may bleed longer after an injury or they can experience spontaneous bleeding into the joints and muscle depending on the severity. There ae three types of hemophilia, Hemophilia A, B, and C. Hemophilia A and B are the most common types. In the past hemophilia affected life expectancy but currently with improved treatment, individuals with…

Epidemiology Hemophilia is one of the most dangerous inherited bleeding disorders, affecting people from the entire world in equal frequency. Overall, the affected population frequency is low and the diagnosis of this disease is inherited about 70% of the time. Sometimes, hemophilia can occur when there is no family history of it and this is called sporadic hemophilia, having approximately 30% of people with non-inherited hemophilia, caused by a change in the person’s own genes…

Born in St. Joseph Memorial Hospital in Kokomo, Indiana, Ryan White was the little baby of Hubert and Wayne White. After being circumcised, the bleeding would not stop and after 3 days old, he was diagnosed with severe hemophilia A. He received a weekly infusion of Factor VIII (a blood product created from pooled plasma of non-hemophiliacs (Brannon, n.d.)), it is a common treatment for hemophiliacs at that time. He became extremely ill with pneumonia in December of 1984 even if he was healthy…

Thesis and Description- Hemophilia is a hereditary disease where the body lacks certain blood clotting factors because of a defective gene. (worldbookonline.com) A hemophiliac’s blood lacks the active form of one of these factors.(worldbookonline.com) People with this disease experience excessive, or even fatal bleeding. (galegroup.com) Number of people affected – It is estimated that 10,000 people are born with this disease. It is a lifelong and chronic illness. (google.com) Life Expectancy- as…

Hemophilia A and B is a bleeding disorders, congenital where the adults and children can have blood clot inherited condition. Children with hemophilia condition, have a bleeding problem and do not stop bleeding as quick as other children. For people who does not have hemophilia, a little, small cut its not a such big problem but, people who suffers from hemophilia, this little cut is deep bleeding inside their body. Especially it affects their knees, ankle, and elbows. In many occasion people…

Hemophilia is a medical condition in which the ability of the blood to clot is severely reduced causing the sufferer to bleed severely from even a slight injury. There are four types of Hemophilia which are Hemophilia A-Also called classic hemophilia, it is four times more common than Hemophilia B, and it occurs when factor VIII levels are deficient, Hemophilia B-Also called christmas disease, it occurs when factor Xi levels are deficient, Hemophilia C-It occurs when facts of XI levels are…

Introduction Originating from the Greek words ‘haima’, meaning blood, and ‘philia’, meaning friend, hemophilia is a medical condition in which the individual lacks a certain clotting factor which prevents bleeding as a result of injury. In order of rarity from most to least, it features type A, B and C hemophilia and various severity levels. Type A hemophilia consists of 90% of cases, in which the individual lacks clotting factor VIII and 70% of patients have a severe level of hemophilia.…