Glutathione

Since leukotrienes have a major impact on asthma, researchers then began questioning where they were derived from. Leukotrienes are formed from omega 6 vegetable oil, which is also known as linoliec acid. Researchers have discovered that the way we eat is one of the major causes of asthma and allergic reactions. Eicasonoids generated from PUFA, particularly omega 6 are some of the early substances released in the lungs during an asthma attack. Omega 6, however, is not the only substance that…

Romidepsin is a bicyclic compound that acts as a prodrug within the body. A prodrug is a drug that is originally inactive until the body metabolizes it and turns it active. In the case of Romidepsin, glutathione in the body’s cells reduce the drugs disulfide bridges, thus allowing the free sulfur groups (forming thiols) to interact with zinc ions in class I and II HDAC’s active sites. Romidepsin can have multiple target genes, however the most important…

Glutathione addition in semen extender up to a level of 2 mM was found to be protective against the damaging effects of free radicals, beyond that no protective effects were found in bull spermatozoa (Bilodeau et al., 2001). The addition of. .glutathione to the semen extender prevented the loss of sperm motility by inhibition of lipid peroxidation caused by ROS in frozen thawed bull semen (Bilodeau et al., 2001) and goats (Sinha et al., 1996). Moreover, glutathione increased the viability…

The samples were loaded into a 96-well plate and diluted 1:2 with a co-substrate mixture containing NADPH, glutathione and glutathione reductase. The assay included negative and positive controls. Cumene hydroperoxide was then added to initiate the reaction and the consumption of NADPH was monitored at 340nm at five different moments. One unit of GPx is defined as 1ųmol…

Cosmetic tanning has become the safe option for people seeking a suntan. Professional spray tan applications are available from spas and salons by hand-held sprayers and involves spraying the tanning solution over the entire body. This is considered the best option for a safe tan with a professional finish without dangerous side effects. This is often used for one off special occasions and for those clients that wish to have a natural looking tan without damage to the skin. Some people may use…

Acetaminophen is classified as an analgesic and an antipyretic. It is also one of the most commonly used medications to relieve pain in the United States. “Approximately one-third of the people in the United States report using an acetaminophen product at least once a month” (Aschenbrenner, 2006). The most common brand name for the over-the-counter medication is known as Tylenol, however, acetaminophen is also a major ingredient in many over-the-counter cold and flu medications, such as…

cells exhibited convolution of the cell membrane, electron dense cytoplasm, irregular heterochromatic nuclei and few secretory granules. These changes might be due to DNA damage secondary to lipid peroxidation, excess reactive oxygen species and glutathione depletion causing cell cycle arrest (8). In agreement with this hypothesis previous studies found that lipid peroxides react with Fe‏2 in the nucleus to generate the…

Insults to the Central Nervous System (CNS) result in debilitating consequences and often leave affected individuals with permanent damage. Reactive astrogliosis is a response to CNS trauma or disease is characterized by astrocyte activation, proliferation, up regulation of the structural intermediate filament protein glial fibrillary acidic protein (GFAP), cellular hypertrophy, and development of a pronounced stellate morphology (Lee et al., 2000; Liu et al., 2000; Messing and Brenner, 2003).…

Introduction: There are many interactions between nutrients which can affect their absorption and impact on your health. Many manufacturers and consumers don't realize that improper mixtures of in gradients can have serious hazards. for instance, calcium supplements may lead to zinc deficiency as calcium can block absorption of zinc. Anyone can mix nutrients and sell you a pill, and you can buy a variety of vitamins and minerals in the store and take them but getting the scientifically justified…

Introduction Doxorubicin, an anthracycline antibiotic, is commonly used as an effective antineoplastic agent, in the treatment of various of malignancies, including leukemia, lymphoma, and solid tumors. Unfortunately, the clinical use of this drug is limited by cumulative dose-dependent cardiotoxicity, which may cause irreversible and severe effect of cardiomyopathy [1] The specific mechanisms of doxorubicin (DOX) induced cardiotoxicity are complex and although decades of research on this drug,…