Glucocorticoid

One of the most broadly discussed and notorious areas of human presentation and performance, concerns the use of steroid supplements to boost the physical ability of a person for an assortment of sports that range from bicycling all the way to basketball. There is verification that some people (athletes, to be more specific) have attempted to improve their performance by using steroids since the 1950’s, but whether, and in which types of sports, steroids are in fact successful remains…

neuroplasticity, endocrine and immune system in animals and humans (Dantzer and Mormede, 1995). Chronic restraint stress models are the most popular for studying the mechanisms of impairments or cognitive disturbances (Chen et al ., 2010; Yi et al.,2013). Glucocorticoids are able to modulate many cellular processes such as energy and neurotransmitter metabolism (Datson et al ., 2008) which are all the intervening elements in response to stress and in the restoration of homeostasis. Authors have…

Stressors in adult life, both short- and long-term, can adversely affect mood and behavior, as well as physiological functioning. Because stress, anxiety, and depression have physiological effects it is important to understand how maternal stress responses impact fetal development. Fetal development concerning organizational influences of the nervous system is termed “programming” (Davis et al., 2007). The timing of fetal development in relation to maternal physiological responses influences…

steroid medication (Kee, 2012). The most common steroid medication is a glucocorticoid (Rathee, 2013). The main glucocorticoid is Cortisol. This has antiinflammatory effects that is used to treat inflammatory, allergic and debilitating conditions. Many autoimmune disorders require a glucocorticoid, including multiple sclerosis and rheumatoid arthritis (Kee, 2012). It is very common for a person to be taken a glucocorticoid therefore it is important as a health care provider to ask your patients…

effects of DMARDs, so close monitoring of liver function as well as blood cell levels regularly is essential. Glucocorticoids are also used as a means to suppress the inflammatory response of the body, decreasing the progression of rheumatoid arthritis. They are typically used only when DMARDs are being started to allow the effects to take place more effectively. Long term use of glucocorticoids is not recommended because of the high risks associated with long term use such as: hypertension,…

There are two primary concerns for the anesthesiologist. The first is thyroid storm is a life-threatening syndrome and requires immediate recognition and treatment. The second is diagnosis and treatment of the underlying disorder causing thyrotoxicosis. Clinical evaluation of patients with suspected thyrotoxicosis is important because it may reveal a specific cause. Attention should be paid to the neck, eyes, neurologic, cardiac, pulmonary, and integumentary systems.8 The plan for a…

disease can be caused by both outside and inside influences of your body. It occurs after prolonged exposure to increased levels of exogenous (delivered externally) or endogenous (delivered internally) glucocorticoids ,which are corticosteroids that bind to the glucocorticoid receptor. Synthetic versions of the cortisol hormone, corticosteroids,…

involved in the production of antibodies were down-regulated. This explains why lonely people are more susceptible to inflammation-driven cardiovascular diseases and have poorer responses to viral infections. Until recently, it was unknown why the glucocorticoid receptors were…

Case Study: Clinical Biochemistry investigation into Addison Disease Introduction A fifteen year old male presented to the Emergency Department (ED) with his mother in St. Vincent’s University Hospital (SVUH) on the 8th September 2017 with suspected Addison disease (AD). On initial examination he was found to have severe abdominal pain and prolonged vomiting. Other symptoms could include fatigue, myalgia, weight loss and salt craving (Brooke & Monson, 2017). Laboratory Investigation and Results…

recovery (the fast-track methodology) (Kehlet 2008, Kehlet and Wilmore 2008) Several trials have demonstrated a reduction in the inflammatory response, postoperative nausea and vomiting, and pain by administration of preoperative glucocorticoids. 15–19 In fact, glucocorticoids have been used in EVAR, this approach has been tested in a randomized setting. One of these study is The Intraoperative Methylprednisolone in Endo Vascular Aortic Repair (POMEVAR). The idea with this study, was the hope to…