Genomics

Hypothesis: 1.) Animals with nocturnal sleep cycles will have greater similarity in the PER gene than the PER gene of diurnal animals. 2.) Differences in the sequences of PER genes can account for variance in the free running period (FRP) between varying organisms. 3.) Human PER gene homologs arose from prior duplication events throughout evolution. Motivation and Background: The biological clock is an endogenous mechanism that regulates the physiological activities of an organism. It was…

expression can also vary between tissues, developmental stages, and species. Imprinted genes are involved in differentiation, development, viability and metabolic functions(Lee et al., 1999). In Lee et al., they demonstrated that two main clusters of genomic imprinting are known in humans: a region at 11p15 containing several imprinted maternally expressed genes like H19, KNCQ1 and paternally expressed genes like IGF2, INS, KCNQ10T1 (LIT1). The second cluster is at 15q11-q12 and contains at…

huge leap of deciphering the intricacies of the human genome twelve years ago, the common man benefited in ways unknown to him. And, as more and more data flowed in, the healthcare domain embarked on a new and renewed journey, lead by the field of genomics. A personalized approach to medicine is now heralded as the new future of healthcare—a unique and defined way to move forward which will not only trim healthcare costs but also improve care by doing away with ineffective treatments. However,…

Zika Virus Zika Virus is a fairly new Virus, the first big outbreak was reported in 2015 in Brazil. Zika Virus is fairly new in the United States, but scientists now know that it comes from a mosquito. The virus attacks the reproductive system in women. It’s the most harmful to women who are pregnant. When pregnant women get Zika, it will cause the baby to be born with microcephaly. Microcephaly makes the baby’s head smaller than average. The Zika Virus affects the reproductive system. The…

The 1918 “Spanish flu” Pandemic was caused by an avian-like influenza virus that gained the ability for efficient and sustained human-to-human transmission and then spread globally, killing 20-50 millions. Fortunately, viruses with pandemic potential are rare occurrences and ongoing surveillance of human and avian viruses is being done globally in preparedness for an influenza pandemic. Vaccines and anti-viral drugs may be available, if needed and time permits. Both kinds of therapies have…

in specific components of neural circuitry for establishing long-term memories. The proposed project addresses this important problem by employing a multidisciplinary approach in which we systematically combine tools of imaging, state of the art genomics and bioinformatics, molecular biology, functional analysis and electrophysiology. The proposed research is highly significant due to the following six major reasons: (1) Translation is affected in several neurodegenerative disorders. Several…

Background: Francisella tularensis (F.tularensis) is the etiological microorganism for tularemia. There are different forms of tularemia such as respiratory tularemia. Respiratory tularemia is the most severe form of tularemia with a high rate of mortality; if not treated. Therefore, traditional microbiological tools and Polymerase Chain Reaction (PCR) are not useful for a rapid, reliable, accurate, sensitive and specific diagnosis. But, DNA microarray technology does. DNA microarray technology…

The same reaction mixture without genomic DNA was set up to serve as a negative control. The PCR reactions were then amplified in a DNA thermocycler (G-Storm GS1 thermal cycler, GRI Ltd., Gene House, Essex, United Kingdom) programmed as follows: (1) 94°C for 2 min (initial denaturation);…

Mr A is 76 year old male who is living alone. His wife died before 1 year. He is taking care of himself. He has history of non-insulin dependent diabetes mellitus. He is on insulin injections for control of diabetes. He has history of hypertension, osteoarthritis, ischemic heart disease, obesity and gastroesophageal reflux disorder (GORD). He suffered from recent fall and underwent hip replacement surgery. He is shifted in rehabilitation centre after surgery. In this paper author will analyse…

organs, what people usually refer to as “biological sex”, gender and gender norms are a product of the society in which they are expressed. Our western society has ideas of masculine and feminine that are conflated with XX and XY. For this reason, genomics neither explain nor refute the possibility of transgender identities, however, the huge amount of transgender people in our population provides convincing evidence of the existence of trans…