Genetic marker

PDAC biomarker identification and validation. Biomarkers in ex vivo expanded CTCs will be recognized by stringent statistical analysis and subjected to further characterization in three studies. First, we will confirm the association of biomarkers with CTCs and CTC-PDX models. Second, the biomarkers will be validated for correlation with clinical PDAC metastasis and therapeutic resistance. Finally, we will retrospectively test the application of selected biomarkers in PDAC diagnosis, treatment…

melanogaster, otherwise known as the common fruit fly has been a useful organism to the field of genetics. It has a relatively short generation time of approximately 10 days at 25 degrees Celsius, and yields a large amount of offspring. This results in large amounts of data over a short time period. In this lab, the purpose was to demonstrate how the Drosophila melanogaster is used in the field of genetics to study the inheritance of traits throughout the F1 and F2 generations. Drosophila…

major role in evolutionary and genetic studies. Polyploidy is characterized by the presence of multiple sets of genomes in the same organism. It is one of the major causes of speciation; thus, is it plays a major evolutionary role in angiosperm development. Its genome undergoes remarkable changes in function and structure through genetic and epigenetic changes. Epigenetic changes are mediated by RNA and chromatic remodeling and occur vie regulatory pathways. Genetic changes occur through…

Assignment: 17TH SEPT 2015 GENETIC COUNSELLING, ETHICAL ISSUES IN MANAGEMENT OF HEMOGLOBINOPATHIES Objectives 1. Describe risk assessment in genetic counseling One of the most important aspects of genetic counseling is the provision of a risk factor. Estimation of the recurrence risk requires consideration of: i) The diagnosis and its mode of inheritance ii) Analysis of the family pedigree iii) The results of tests, which can include linkage studies using DNA markers. The probability of an…

Ehler’s Danlos, EDS for short, is a genetic connective tissue disorder caused through abnormalities in the body’s processing, production, and or integral structure of collagen(Mayo Clinic, 2017). Ehler’s Danlos is what numerous call chronic and degenerative; a patient may endure this particular condition with no hope for a cure throughout their entire life, as the disease rapidly progresses. Most diagnoses face a lifelong commitment to the syndrome and pains that plagues them. This is…

In terms of genetics, technology has advanced far enough to map out the human genome. As a population, we have found out that there are no ethnic markers that differentiate us from one another, with genetic variation sometimes being greater between two individuals of the same race than two individuals of different races. Even with the knowledge that the human genome insists the lack of a biological race, the persistence of the basal human need to categorize humans into ethnic categories begs the…

of both nature and nurture that shapes human outcome. I tend to look at it like this: we cannot escape our genetic predispositions, but we can change the psychology surrounding them. Thus, it is possible to raise a child who had an incredibly dire utero experience into a functional, happy person and vice versa. Paul gives explanation of this with regards to PTSD and how this genetic marker could be both a hindrance or survival testimony (Paul, 2011). So, I cannot say that I fall on one spectrum…

The random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) method was used to examine the genetic variability of Aiolopus thalassinus (Fabr.) populations at heavy metal polluted and unpolluted locations of different geographical distances. Four primers yielded a total of 69 scorable bands, which are all polymorphic. Cluster and Principal component analysis separated the inside and outside Cairo populations into two main branches that were further separated into smaller ones,…

An insight into the methods of Conservation Genetics Understanding the need to use genetic methods in conservation biology will greatly aid in the process of bringing back any species that play an important role in their native habitat. Implementing genetic tools and methods in conservation programs helps to minimize the loss of genetic diversity, which allows populations to adapt to environmental changes and stressors. This helps to minimize the loss of the population numbers by reducing the…

Introduction: The definition of Genetically Modified Organisms in the Britannica Encyclopedia is given as “Genetically Modified Organisms (GMO) is the organisms whose genome has been engineered in the laboratory in order to favor the expression of the desired physiological traits or the production of the desired biological products”. From the definition we can understand that the genome from the DNA can be altered or some sequence can be separated from the DNA and use it to enhance or mute (gene…