Gene expression

mutation on the LMNA gene (Burtner; Reunert et. al, 2012; Rodriguez et al., 2009). The genetic cause of Progeria is a mutation on the LMNA gene located on Chromosome 1 (Gulli & Mallory, 2002; Reunert et. al, 2012). Specifically differentiating Progeria from other laminopathies is that the mutation is located on exon 11. The LMNA gene encodes for A-type Lamins which are the inner nuclear lamina involved in maintenance of the nuclear shape and structure, DNA replication and gene expression…

Dyskeratosis congenita (DKC) is a rare congenital disorder that results from defects in telomere maintenance due to mutations in genes coding for proteins that participate in telomere maintenance. It is a progressive disease with a highly variable phenotype, making diagnosis difficult. The disease is characterized by the classic triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia (white patches in the mouth) (Figure 1) but these symptoms might not always manifest in…

Addition of the Plasmid vs the Expression of the Added Plasmid Introduction The earliest example of genetic engineering was performed by Gregor Mendel in 1865, when Mendel performed artificial selection on a population of pea plants in the monastery where he lived (http://www.sciencegroup.org.uk/ifgene/history.htm). Once the technological advancements of the 20th century was introduced to the science field, genetic engineering took on a whole new light. Scientist could now transform organisms in…

natural selection, mutation, gene flow and genetic drift. Natural selection is the process involving the organism adapting to environmental factors. This could be factors such as climate, availability of food sources and predation. Organisms that have physical characteristics that enable them to flourish their environment will survive to reproduce, passing those beneficial characteristics onto their offspring. Those organisms with undesirable traits will die without…

enables the scientists to answer the precise questions about the behavior (Bellen and Tsuda 2010). The currently available genetics tools like Gal4/UAS system and the RNAi screening makes one to make accurate mutations and hand on controlled gene expression. The courtship rituals of male D. melanogaster have a special interest in the field of behavioral studies. It often contributed to the studies related to learning, memory, information processing and execution of various behaviors…

using a rate analysis and computer simulations, they found that protein evolution rate in humans, compared to that of other primates, was significantly higher in human FOXP2 (Zhang et al. 2002). This provides a potential mechanism by which the FOXP2 gene evolved differently in humans. Although their analysis was thorough and insightful, other studies with different strategies that further confirm this potential mechanism…

there are many codons in the whole genome, which is very difficult for scientist to replace all instance of seven codons. The propose of multiple codon replacement can be done by simultaneously edit multiple alleles using MAGE, a machine that process gene modification, or Cas9, an enzyme, both require more steps and other ingredients and equipment. Moreover, there is also high chance to cause mutation. To compensate, the team designed a computational and experimental tools to construct the…

Aims/Objectives of Investigation I am intrigued by the process of clinical investigation and the development of medical care in disorders that currently immedicable and incurable. My prime aim for this project is to examine and investigate the current state of medical research regarding treatment, therapies and understand the leading solutions in the aim to cure Tay-Sachs disease. This includes exploring the achievements attained and challenges facing the medical researchers and clinical…

expanded on the knowledge base surrounding how HU induces the γ-globin expression in cord blood cells. While this does not combat the β6 point mutation, the γ-globin upregulates the amount of HbF that is produced in the body. The use of cord blood, is warranted here because the goal of the research is to study the genes that are regulators of γ-globin. In order to have a better grasp on the increased production the group analyzed the genes that are expressed on miRNA which will code for this…

to identify similiarties. Our planet is home to billions of different organisms, each with unique charactersics. Within the infinitely large range of diversity, all organisms share one cominality; the backbone to all characteristic; DNA and gene expression;. Within a specific species, there are thousands of possibilities for how a specific set of DNA will be expressed. Though there are 1000s of possible combinations, a species must have a method to be able to become better suited for the…