Functional group

The carbodimide chemistry reaction involves first the activation of the carboxyl group using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide EDC and then a covalent reaction between free amino group and activated carboxyl group in PEG-EGFR and PF0-HNC respectively [42]. In brief, 10 mg of Methoxy-PEG-COOH and 5 times molar excess of the EDC was dissolved in 5 ml 0.1 M MES buffer (pH 4 ~ 5) under continuous…

CHAPTER 2 LITERATURE REVIEW 2.1 Synthesis of Schiff base Method preparation for Schiff base ligand is a straight forward synthesis and easily modified using different amines and carbonyl compound. This could be one of the reasons that make Schiff base ligand popular in coordination chemistry research. Synthesis of Schiff base ligand commonly, taking place in alcohol through condensation reaction of amines and carbonyl compound. The acid/base catalysis or heating is employed in the synthesis…

Four different were gathered from the IR spectroscopy to identify the nitrophenol. The first peak observed was a weak and broad at 3314.75 cm-1, which was corresponded to an alcohol group; therefore this peak must be corresponded to the O-H stretch of the phenol with a literature value that ranges from 3550-3500 cm-1 (Figure 5). The variance between the observed value, and the expected value can be due to the MHz of the IR spectrometer used. The second peak observed was a weak-medium, sharp and…

The sequence of the reactions employed for the construction of novel indole–benzimidazole-based 1,2,3-triazole hybrids is demonstrated in Scheme 1. Compound 2 was prepared by treating propargyl bromide with 1H-indole-3-carbaldehyde (1) in presence of potassium carbonate in dry acetone at reflux temperature [26]. Compound 2 was further reacted by heating at reflux temperature with o-phenylenediamine (OPDA) in chloroform for 6 h afforded compound 3. Compound 3 coupled with variously substituted…

Experiment 11: Peptides and Amino Acids The purpose of this experiment was to study the amino acid composition of artificial sweeteners and then observe simple acid and base catalyzed reactions of the amino acid and artificial sweetener aspartame. This was achieved by performing a TLC analysis using ninhydrin as an indicator to observe the composition of the amino acid as well as two of the components that make up aspartame. This is followed by the addition of an acid or base to aliquots of diet…

Benzoylmethylecgonine is an organic compound found in the leaves of Coca plants. This organic molecule is also called methyl(1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate using the systemic IUPAC system. It has a chemical formula of C17H21NO4 and has a molecular weight of 303.353 g/mol. It is commonly known as Cocaine or Coke. Discovery of Cocaine When the Spanish arrived in South America, they discovered that coca leafs that the aboriginals chewed on gave them…

OMEGA-3 FATTY ACIDS 1) Structure Figure 1.1 The omega-3 fatty acids are also known as ω-3 fatty acids or n-3 fatty acids which contain a long chain of polyunsaturated fatty acids and the chain ranges from 18 to 22 carbon atoms (Collins J.J., 2010). The fatty acids have two ends; the carboxylic acid end (-COOH) and the methyl end (-CH3). The carboxylic acid end is considered the starting of chain which is “alpha” and methyl chain is considered as the tail of the long chain…

INTRODUCTION Conformational isomerism is a type of stereoisomerism whereby the isomers are interconverted by rotations about the single bonds. There be terms used below such as eclipsed conformation, staggered conformation,dihedral angle and a few more. Eclipsed conformation is the conformation whereby the C-H bonds on one carbon is directly aligned with the C-H bonds of the adjacent carbon. When the C-H bond of one carbon bisects the H-C-H bond on the adjacent carbon, it is known as staggered…

Carbonyl compounds are the compounds the contain C=O group which is called carbonyl group (double bond oxygen to a carbon). There are many types of carbonyl compounds such as aldehydes, ketones, carboxylic acids, esters, amides etc. Aldehydes and ketones are the oxidation products of alcohols. Depending on the alcohol’s structure, the product obtained will be different. Primary alcohols have one carbon and two hydrogen atoms attached will produce aldehyde and then to carboxylic acid in two…

WHAT IS FORMALIN? Formalin is the trade name for an organic compound made by formaldehyde and water. It has the chemical formula CH2O and its chemical structure is as shown in figure.1. Uses: Formaldehyde is used mainly in the production of plastics (such as urea-formaldehyde plastics which is used in many manufacturing processes due to its useful properties such as flexural modulus, and a high heat distortion temperature, high surface hardness, low water absorption, high tensile strength, mold…