Formulations

3A.2.10 Robustness A method is robust if it is unaffected by small changes in operating conditions. To evaluate the robustness of developed analytical method few parameters were deliberately changed. The parameters included analysis at different temperatures viz. 250C and 300C, at 0.8 and 1.0 mL/min flow rate, using C18 columns from different manufacturers one from Qualisil BDS, USA (4.6 x 250 mm x5µ) and the other from LC-GC, India (4.6 x 250mm x5µ). Each of the three selected factors were…

All human beings have free will to make decision but more importantly, everyone have good will. For Kant, good will has “whole value in itself” and “ its usefulness or fruitlessness can neither add to nor take away anything from this value”. Likewise, most individual would act to get something good out of it. However, the moral value of an act cannot rest on the consequences because a will is only good when it is good in itself and not what it accomplishes. Therefore, it is essential for Kant…

NANOCARRIERS AS PROMISING NOVEL SYSTEMS FOR CONTROLLED DELIVERY OF DICLOFENAC SODIUM [N.B: Authors' details blinded by Pro Journals for Review] ABSTRACT The formulation and evaluation of Diclofenac sodium from liposomes, niosomes and nanoemulsion are analyzed. The release profiles of Diclofenac sodium were almost similar in all the formulations. It is found that 85% of Diclofenac sodium diffused out from the colloidal systems within 8hrs and practically all the drug was released within…

Introduction Cabozantinib, developed by Exelis Inc. as initially XL185, was first FDA approved in 2012 under the brand name CometriqTM. There are two formulations of cabozantinib in which CometriqTM is an oral capsule and has the clinical advantage of a quicker delivery time in comparison to its tablet form (CabometyxTM). Bioequivalence for the formulations are not the same, a 19% higher Cmax for the tablet form, and should not be used interchangeably. The current essay will focus on the drug…

The study of antiobesity was evolved when the polyherbal formulation of Foeniculum vulgare, Glycerrhiza glabra, Achyranthus aspera, vigna angularis. The study was applied on the Wister rat and all the biochemical parameters total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, free fatty acid were estimated. The parameters showed significant decrease in body weight and HDL cholesterol. Finally polyherbal formulation was a high fat diet diseases control…

A Moral Theory makes an action right and wrong. Utilitarianism(Mill), Deontology(Kant), Virtue Ethics( Aristotle), and Care Ethics (Held) are some of the moral theories introduced by ancient great philosophers. These principles or theories are used in resolving difficulties and making the moral decisions. Mill introduced an idea of Utilitarianism, the moral worth of an action based on its consequences. Immanuel Kant’s theory of Deontology is the moral worth of an action determined by the…

conduct a background review of details that assist in drawing the baseline variables that help in comprehending the current condition for the identification of the critical improvements needed (Bassuk & Washington, 2013). The third step is the formulation of hypotheses, where the investigator attempts to make educated guesses or predictions of answers to the identified problem. According to Neville-Neil (2013), a hypothesis may be true or false, but it must be a testable idea that leads to the…

Parenteral formulation of an anticancer drug candidate – Tackling poor solubility 1 Introduction Cancer is the number one cause of death in Singapore , and has been on an increasing trend over the years . Hence, the search for anti-cancer drugs and better treatment regimens are widely studied but there are many challenges. One potential cancer treatment strategy is to induce apoptosis in cancer tissues by the modulation of nitric oxide production . Nitric oxide is a reactive, gaseous molecule…

Carol Berkin is a professor of History at Baruch College, and she teaches early American and women’s history. A BRILLIANT SOLUTION: Inventing the American Constitution is a book that involves the independence of United States of America. The years after the Rebellion were the greatest years and the most terrible periods. Even if the nation is eminent their newborn liberty, they did not have a strong central administration that would connect them mutually (Berkin, 2002). Berkin amazingly…

An antacid is composed of a basic chemical compound (the active ingredient), which is an essential component of a neutralization reaction. When this compound along with an acidic compound (HCl) dissociates, it react and form neutralized components such as water and a salt. This is an ideal mechanism of action for individuals who suffer from acid reflux or heartburn conditions because the excessive HCl that is found in the stomach can be alleviated by ingesting antacid tablets. This experiment…