Fluorescence

Phosphonates as inhibitors for Pks13-TE Hypothesis for the aim 1 of the proposed project is that the fluorinated α–Aminophosphonates as a covalent irreversible inhibitor for the Mtb Pks13-TE by scission of the P-C bond. Previous studies have shown the fluorinated aminophosphonates (FAPs) demonstrated serine esterases inhibition via scission of the P-C bond as shown in Figure 2.1.A 4. FAPs are known to irreversibly inhibit serine esterases such as acetylcholinesterase16 , neuropathy target…

Cancer is a disease affecting the world and the rise in treatments with drugs is just one way of delaying the process of the disease as well as improving the quality of life for the patient. Henceforth Amsacrine is one to watch out for due to its specific mode of action. Reference. Amsacrine has an acridine chromophore with an amine at the 9 position (fig 1.) used in the treatment of some types of lymphoma or acute adult leukaemia [5]. It can also be known as Amsidine or m-AMSA [1]. Lymphoma…

an electric circuit, an inductor used in the early forms of radio transmission antennas. The function of the coil simply cooperates with a capacitor to resonate current and voltage from across the circuit a power source. This helped Tesla study fluorescence, x-rays, radio, wireless power, and electromagnetism in the earth and the…

The Metropolitan Museum of Art has an impressive collection of Attica art, a region surrounding the ancient city of Athens; the one most captivating to me was the Marble Capital and Finial in the form of a Sphinx. The Marble Capital and Finial in the form of a Sphinx, was purchased through Martin Birnbaum in 1936, and it was said to be from Kataphygi, Attica. In the Archaic period, during the sixth century BC, sphinxes appear on top and inside Greek temples. In Greek mythology, the sphinx is…

anti-Calbindin as our primary antibody, Goat anti-Rabbit 488 IgG as our secondary antibody (“488” meaning that the fluorescent dye is excited at a wavelength of 488nm, fluorescing green), and DAPI-mounting serum as a DNA (nucleus) marker with blue fluorescence for reference against anti-Calbindin-marked GABAergic neurons (Lammel, 2016). While GABAergic-neuron-expressing anti-Calbindin labeled various regions of the brain such as, midbrain reticular nucleus (MRN), Red nucleus (RN), Substantia…

metal plate while the rays are drawn to the positively charged or anode. The cathode and the anode are located at the ends of the cathode tube. The anode is a specially coated flat surface. As the rays strike this surface, they produce a strong fluorescence or bright light. Back in Asia, my family members own a cathode ray tube (CRT) TV. They find them the least expensive and extremely reliable. I had one at my house and I felt that the TV worked pretty well on day-to-day basis. It was…

For the purpose of this assignment, I researched an article titled, “The Role of DJ-1 in the Pathogenesis of Endometriosis” by Priyanka Rai and Sisinthy Shivajj. The article discusses many components in which are relevant to the disease, endometriosis. Endometriosis is a disease among women in which causes infertility and severe pelvic pain along with other health concerns. It is seen to occur within 10% of woman whom are of a reproductive or sexually-active age. It is due to the occurrence…

Polymerase chain reaction (PCR) Generalities PCR is a method developed in 1985 by Kary Mullis and to obtain, by coupling a heat-resistant DNA polymerase and without cloning, amplification of a fragment of DNA known. Initially, DNA polymerase was isolated from a bacterium thermophilne (resistant to significant increases in temperature), as Thermus aquaticus (Taq polymerase). Currently, we use recombinant enzymes, whose; elaboration is easier and greater efficiency. The general principle of PCR is…

Abstract: Chemiluminescence is an essential topic in the study of chemistry. The reaction involves mixing two chemicals were to form an excited (high-energy) intermediate that releases energy as light. This experiment first synthesized luminol by reducing 5-nitro-2,3-dihyodropthlazine-1,4-dione, using sodium hydrosulfite (Na2S2O4) and 3M sodium hydroxide (NaOH). The amount of luminol collected was 0.2693 g with the percent yield of 161%. The product of the first reaction was then used to…

Complexation of Cyclodextrins Cyclodextrins (CDs) are most important carriers because of their semi-natural property as it is produced from a natural material i.e. starch, by simple enzymatic conversion. Solubility and dissolution rate of BCS class II drugs can be improved by addition or by complexation with hydrophilic carriers like cyclodextrins. Cyclodextrins have the capability to form inclusion complexes with the guest molecules i.e. poorly water soluble drugs. The formed inclusion complex…