Familial hypercholesterolemia

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    Case Study Praluent

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    For patients with high cholesterol, Praluent, also known by its generic name, alirocumab, is the new FDA approved drug that is effective at improving liver function to lower bad cholesterol (Goldschmidt). Unlike other available medication in the market, Praluent is a completely new class of drug that enhance the lives of many individuals and provides an alternative method for treating cholesterol that will appeal to patients who do not see results from their current medication or experience severe side effects. Most current statins, like Lipitor, block the liver’s production of bad cholesterol. Praluent uses a different method in which antibodies target a protein called PCSK9 that generally maintains high levels of cholesterol in the liver (Goldschmidt). Patients currently have to take statin pills orally once a day. Patients who use Praluent will be required to take 75 to 150 milligrams of injections every other week (Clarke). While injections may not be the most ideal form of dosage, patients need to take it less frequently. It’s not that the existing methods aren’t as effective as Praluent; the current cholesterol-lowering methods just aim at a different cause of the problem. Since Praluent is a completely new drug in the market, doctors will not be expected to use this drug as their primary treatment for patients right away. However, for existing patients who do not see results from their current medication, Praluent is an alternative option that only has one competitor…

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    FM 4 Familial Hypercholesterolemia also known as FM, is a disease of extremely high cholesterol levels beginning early in gestation. It is passed along from family member to family member through a genetic mutation. Most commonly on chromosome 19. Many other chromosomes have now been identified as causing familial hypercholesterolemia…

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    When a group of patients diagnosed with Familial Adenomatous Polyposis (FAP), an inherited form of precancerous polyps that afflicts the lower bowel were given curcumin and quercetin over a 6 month period. The number of polyps in the colon dropped by a 60%; the number of polyps that ceased to grow also dropped by 51%, on…

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    Cardiovascular disease is the leading cause of death in the world with its prevalence directly tied to amount of cholesterol in the blood. The Framingham Heart Study showed the tie between high cholesterol and heart disease. The study found that low density lipoprotein (LDL) was more predictive of heart disease than total cholesterol. The study also suggested that family history made the cause of hypercholesterolemia and not a high just a high fat diet. The pharmaceutical class, HMG Co Reductase…

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    Due to this, a combined liver and kidney biochemical profile was done in 2012, to assess for kidney and liver function, as familial hypercholesterolemia we have an increase of LDL. Increased LDL primarily comes from a liver dysfunction, but increased LDL will have an inhibiting effect on the kidneys and the sodium/potassium activity. • eGFR- Low-79 mL/min/1.73m2 (80-120) eGFR is defined as the estimated glomerular filtration rate. This is often measured in conjunction with creatine levels.…

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    exchange is unequal in charge. Sodium and potassium are oppositely charged thus creating a difference in electronegativity. Also, more positive charges will leave than enter the cell which creates a more positive charge in the membrane/outside of the cell. Interactive Questions 7.9 How is cholesterol transported into human cells? Cholesterol is transported into human cells through receptor mediated endocytosis. Through this process, cholesterol fits on the receptors on the membrane. The cell…

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    2.2 Risk Factors Genetics has a strong impact on atherosclerosis, however only a fraction of cases are due to Mendelian disorders, such as LDL receptor gene mutations. Familial traits that predispose an individual to atherosclerosis include conditions such as, hypertension and diabetes and inflammatory disorders (Crowther, 2005, Falk, 2006, Kumar, 2010). Age also plays a role, as individuals between 40 to 60 years of age are at elevated risk of manifesting atherosclerosis, whilst ischemic heart…

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    Ap Psychology 5.1

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    Review Questions # 5 2. Distinguish between autosomal dominant and autosomal recessive disorders and provide a couple examples of each. When dealing with genetic disorders its important to understand how they are inherited. There are two ways a child can inherited a genetic disorder from their parents. Autosomal dominant disorder is where one parent has a genetic disorder in which it has already manifested such as familial hypercholesterolaemia, marfan’s syndrome, and…

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    Alirocumab Research Paper

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    According to the American Pharmacists Association, as of late July, Alirocumab, a PCSK9 inhibitor, obtained FDA approval. In addition to diet and aggressive statin therapy, Alirocumab acts as an aid for patients that have clinical atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. These patients are required to lower their cholesterol further. Alirocumab, a monoclonal antibody which is self-administered through subcutaneious injection every two weeks, lowers…

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    Is there any reason to ditch the yolks? For some maybe, but not for most. For those individuals with diabetics or familial hypercholesterolemia, it's probably best not to have three eggs per day. Athletes competing in weight-class structured sports may be cutting calories. So cutting weight by removing the yolks could help keep protein higher. This in turn preserves muscle mass) while at the same time keeps calories lower. So breaking it down; each egg yolk contains 6 g of fat and 54 kcal.…

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