Extracellular matrix

Introduction All animals can heal their wounds. However, some animals can even regenerate lost body parts. Questions have arisen such as, how does this process take place? What is necessary for these animals to perform this job? Experiments have shown that different animals regenerate in different ways. Some may be similar than others and it may have an impact on their lives. The purpose of regenerating tissues is to limit damage and loss of infection. The processes of tissue regeneration…

least an inability to function properly. One of the proteins made by the virus is called Ebola virus glycoprotein. The glycoprotein can disrupt cell adhesion, so that cells have trouble sticking to each other and to a scaffold called the extracellular matrix, which in healthy tissue helps to hold the cells…

Considering the evaluation of a high-tension area, such as the hand, treatment is guided by initial control of bleeding, prevention of infection, physical assessment, obtaining a health history, allergies, current medications and tetanus immunization history. Primarily, a focused assessment for the presence or absence of tendon, vascular or nerve damage, taking wound measurements, exploring the mechanism of injury and the length of time since the initial injury is paramount. As might be…

muscular dystrophy, Duchenne Muscular Dystrophy. Duchenne Muscular dystrophy is caused by an absence of a protein that keeps muscles in tact, dystrophin. Dystrophin is the protein responsible for connecting the internal cytoskeleton and the extracellular matrix. It acts as a protectant against the sarcolemmal membranes contractions. It affects 1 in every…

In philosophy, an often debated question involves whether or not the dead can be “wronged”. Slander is mostly agreed to be wrong, regardless of the character of the dead. However, could genetic testing have the same result? One great example is Abraham Lincoln. Lincoln fascinated physicians because of his remarkable stature (6’, 4”) which has been possibly linked to Marfan syndrome. Abraham Lincoln was unusually tall as a child and his extremities were disproportionately to his overall height;…

1.3.1 Hyperacute rejection Hyperacute rejection occurs immediately after transplantation, typically within minutes to hours. It is due to the presence of preformed antibodies in the recipient’s serum which are either directed against donor HLA antigens (referred to as DSAs) or ABO blood group antigens located on the graft endothelium {Chan:2000ui, Howell:2010fg, Overviewoftranspla:2013ty, ImmunologicAspects:2002tn}. Following anastomosis and blood flow into the graft, the antibodies bind to…

lead to delayed wound healing and recovery (Sgonc & Gruber, 2013). Therefore, Mrs. C. C. may have these bruises on the skin for a longer time. Also, being post-menopausal her levels of estrogen have declined, and this can lead to reduced "extracellular matrix deposition" and inflammatory responses (Sgonc & Gruber. 2013, p. 163). These mechanisms can lead to a delayed healing process. Care Plan Assessment The assessment of Mrs. C. C. would need to begin with a complete history and physical…

Comparing with other disabilities, diseases, spinal cord injury is a critical disorder in worldwide. Physiology and anatomy The spinal cord(SC) is a grayish-white structure that begins superiorly at the foramen magnum in the skull, where it is continuous with the medulla obolongata of the brain. It terminates at the level of the lower border of the first lumbar vertebra. The spinal cord is located within the vertebral canal of the vertebral column, which is surrounded by three meninges: the…

cells of mammalian system such as epithelial cells, inflammatory cells, fibroblasts, osteoclasts, etc. and host gelatinase plays a vital role in the normal physiological processes such as regulation of formation and remodeling of tissues by extracellular matrix degrading functions. Gelatinase has broad spectrum of the substrate which hydrolyses various substrates namely gelatin, fibrin, collagen, fibrinogen, casein, Hemoglobin, Insulin, some sex-pheromone related peptides and other bioactive…

convert into cardiac endothelial cells through the activity of transcription factor p53. The human heart consists of myocytes and non-myocytes. The non-myocytes include cardiac fibroblasts and endothelial cells which generate growth factors and extracellular matrix (ECM) proteins which are responsible for sustaining the…