Extracellular matrix

Past Medical & Surgical History, Pathophysiology of medical diagnoses (with APA citations) 1. Iron Deficiency Anemia: The most commonly occuring cause of anemia. Iron deficiency results in the lack of iron for hemoglobin synthesis within the body. This may be a result of low intake, diminished absorption, physiological increase in requirements, excessive iron loss, chronic renal failure, hemodyalisis, and idiopathic iron loss. (Copstead & Banasik, 2013) KG receives frequent blood transfusions to…

Regenerative Capabilities of Dental Stem Cells Introduction – state hypothesis or problem and its scope (<1 page) Regenerative medicine aims to restore or establish normal function by replacing or regenerating human cells, tissue, or organs (Dunnill). Cell-based therapies are integral in regenerative medicine for the inherent ability of stem cells (SCs) to differentiate into specific cell types (Sedgley & Botero). SCs can be isolated during embryogenesis (embryonic SCs), or in postnatal…

A bone is made up of different tissues that work together: bone, cartilage, dense connective tissue, epithelium, various blood forming tissues, adipose tissue and nerve tissue(coursehero). All individual bones are organs. Bones along with their cartilages make up the skeletal system. Bone makes up eighteen percent of the weight of a human body. There are two hundred six bones in the in the adult skeleton, more than half are found in both the hands and feet. The functions of a bone are support,…

mesangial matrix, interstitial fibrosis, thickening of basement membranes, and renal cell damage. DN affects 20% to 30% of the diabetic patients (1). Many pathways that involved in DN have been postulated such as hyperglycemia, oxidative stress (OS) and activation of protein kinase C (PKC) (2-4) (Table 1). The up-regulation of the receptors for AGE (RAGE) has been implicated as a major mediator in the development and progression of DN. Renal fibrosis characterized by accumulation of…

Besides, it is also believed that by means of some not fully identified molecules, this bacteria is capable of dampening IL-8 production via an inhibitory effect on NF-kB transcription factor. Although some evidence about the role of extracellular polymeric matrix in cytokine modulation is available, further investigations seem crucial…

Cells also secrete various proteins that become part of the extracellular matrix or are involved in intercellular communication. Proteins are sometimes altered after translation and folding are complete. In such cases, called transferase enzymes add small modifier groups, such as phosphates or carboxyl groups, to the…

portion of a cholesterol molecule and it forms hydrogen bonds with the polar heads of phospholipids. d. –OH group 5. This type of membrane protein will extend throughout the entire membrane touching both the Intracellular fluid and the Extracellular fluid. e. Integral proteins f. Transmembrane proteins g. Integral proteins and Transmembrane proteins Ans: D 6. This portion of the cell membrane enables cell membranes to produce chemical products. .…

The pancreas is a compound glandular organ; derived from the endoderm, and is located in the retroperitoneum associated with several vital structures, which complicate diagnostic and therapeutic procedures. Normally it has an average weight of 90 g, and is shaped like a tadpole, that is divided into four main anatomical areas: head, neck, body, and tail (7). The pancreatic head is the thickest portion of the pancreas and lies within the C-loop of the duodenum, to the right of the superior…

in vivo studies of PSC; other subject of study include migration, gene expression, cell signaling, etc.[17]. Yet not many people have look into the mechanical properties of cellular microenvironment by studying the effects of PSC contractility and matrix cross-linking. Therefore, I plan to tackle this issue by focusing in the role of pancreatic SC contractility and cross-linking capability in their interaction with cancer cells and influence in diseases such as fibrosis, pancreatitis, and…

In this phase, the wound is rebuilt with new granulation tissue which consists of extracellular matrix and collagen, and new blood vessels develop. The granulation tissue depends on oxygen and nutrients produced by the blood vessels for a healthy healing process of the wound. The color of the granulation tissue can determine whether or not…