Estado

"The imperialists cannot forgive us to have carried out a socialist revolution under the very noses of the Yankees". In this way on January 1st, 1959 then leader of the 26th of July Movement, Fidel Castro led thousands of guerilla fighters and ordinary citizens of Cuba to overthrow the Fulgencio Batista dictatorship. Fighting the regime of Batista on both urban and rural fronts, the Movement was able to successfully integrate into power in Cuba. The Revolutionary government in its early days was…

ABSTRACT N-Myristoyltransferase (NMT) is an attractive target for the development of novel antimalarial drugs. In this paper, we report a hologram quantitative structure-activity relationship (HQSAR), a comparative molecular field analysis (CoMFA), and a comparative molecular similarity indices analysis (CoMSIA) studies on a series of benzo[b]thiophene-containing selective inhibitors of plasmodial NMT. Two QSAR models were constructed, one for Plasmodium falciparum NMT and another for Homo…