Essential amino acid

of a nuclear receptor coactivator 2, NCoA-2. This similarly occurs in the other half of the complex: RXRα Receptor A type II nuclear receptor as well, RXR-α heterodimerizes with PPARγ. The ligand that activates RXR-α is the ligand 9-cis retinoic acid that results in dissociation of corepressor and recruitment of coactivator protein, also called NCoA (Vikas et.al 2008) . Figure 6. NCoA-2 Transcriptional coregulatory protein proteins interact with transcription…

As transdermal delivery is a non-invasive route for the therapeutic materials delivery from the intact skin towards the systemic circulation. And as every square centimeter of the surface of the human skin contains ≈10–70 hair follicles and ≈200–250 sweat glands, hence the skin surface could be a conduit for the delivery of therapeutic agents. Additional benefits of using transdermal route is being a painless delivery method, few side effects, providing a low-frequency of therapy administration,…

classified as FOXA to FOXR depending on sequence similarities. The FOX family of proteins function as transcription factors and their defining feature is a DNA binding domain known as the fork head domain (Lai et al 1993). This domain is a hundred amino acids long and is highly conserved. It consists of three alpha helices and two large loop regions. The resulting structure resembles butterfly wings and the FOX proteins are sometime refer to as winged helix proteins(Clark et al 1993).…

tertiary, and quaternary. The primary structure of a protein, such as hemoglobin, helps determine the three dimensional structure and properties of the protein. Primary structure is determined by the amino acid sequence; if the sequence is abnormal than the protein will not function properly.14 Amino acids are linked…

The protein that is in sequence one is Alpha-synuclein. Alpha-synuclein is a protein whose function in the healthy brain is currently unknown (Alpha-synuclein and Parkinson's Disease, n.d.). Parkinson's disease researchers take great interest in it because it is a major constituent of Lewy bodies, which are protein clumps that are the pathological hallmark of Parkinson’s disease (Alpha-synuclein and Parkinson's Disease, n.d.). Researchers work to characterize the protein's role in Parkinson’s…

2.0 Experimental Approach Predatory cone snails (genus Conus) produce a rich array of venoms that collectively contain an estimated 100,000 small, disulfide-rich peptides (i.e., conotoxins, or conopeptides). Over the last few decades, the conopeptides have revealed a remarkable diversity of pharmacological function and utility. An evolutionary rationale for the existence of such a large and pharmacologically diverse set of gene products can be premised on the complexity of intra- and…

The structure of an enzyme is important because if the structure of the protein is denatured, the protein can not function properly either. Being denatured can be caused by many things but changing the pH or temperature are the main ways to make a protein not to function properly. Any little change in the sequence from protein folding can cause dramatic consequences that might lead to disease or sickness. Cystic Fibrosis is a common disease that affects the whole body, the main and most…

chemical compound biosynthesized from the amino acids lysine and methionine. It is found throughout all cells in your body. Carnitine is used in producing energy for your body by transporting long-chains of fatty acids into the mitochondria so they can be burned to produce energy. Carnitine is also responsible for transporting the toxic compounds out of the mitochondria to prevent buildup. Skeletal tissues and cardiac muscles use high levels of fatty acids so these tissues are especially high in…

for this experiment was the contamination of the chromatography paper by foreign amino acids. Any amino acids that our gloves came in contact with throughout the lab transfered over to the chromatography paper and appeared as purple spots, mostly on the border of it. Conclusion- The amino acids in unknown mixture A were Glycine and Valine. The amino acids in unknown mixture B were Glycine and Leucine. The amino acids in unknown mixture C were Lysine and Prolise. Questions- The markings from…

thing that they use is something called pre workout or amino acids. What pre workout is a powder that you put in water and it has a lot of caffeine and has a thing called niacin, this makes the blood in your body pump faster to your muscles and causes your veins to pop. What amino acids do is they rebuild your muscles and it brings back energy into your body(Menshealth). The last thing that people take a pills. Pills are pre workout, aminos, and caffeine pills, taking these pills are like taking…