Epidermis

because stem cells are responsible for the continuous regeneration of the epidermis. When a mutation in the LAM5 gene occurs, a highly fatal form of junctional epidermolysis bullosa is created. By using stem cells to create genetically correct skin grafts, patients were able to see relief from a functional self-renewing epidermis. After the application of a stem cell skin graft, patients saw continuous regeneration of the epidermis. This is due to the high levels of stem cells that are in the…

Regeneration is the process of renewal or restoration of a body, part of the body or biological system after a wound or as a normal process. It is the process that makes the genomes, cells and organisms flexible to natural changes that cause disturbances or damage. All species are able to regenerate from bacteria to humans. Regeneration can be of two types: it can be complete when the new tissue is equal to the lost or incomplete tissue when the necrotic tissue presents fibrosis. Different…

layers in the dermis, and is located between the epidermis and the reticular dermis. The papillary dermis is approximately 300-400 µm deep, depending on the age and anatomical location.22 The upper outermost layer of the papillary dermis is arranged into protruding structures called the dermal papillae. The dermal papillae contains microvascular and neural components to support the epidermis. The dermal papillae increase the surface area that the epidermis and dermal papillae interact for a…

In an ideal scenario, the cure for epidermolysis bullosa should be able to replace the defective genes responsible. This should in turn restore proper protein function, so that the structural integrity of the skin can be restored. Ideally, the treatment should have cell, protein and gene therapy. Due to the fact that this condition is genetic, there is no way of preventing it but there are a few things one can do to be alert and informed of the situation. As early as 8 or 10 weeks of pregnancy,…

or third degree burns depending on the layers of skin and tissue that are damaged. As one shall know the deeper the burn the more serious the burn is. First degree burns are burns located at the superficial or outer layer of the skin called the epidermis. It is a minor burn that may appear red, swollen, and very painful. Usually does not cause blisters or scars. It is treatable at home with cold compressions, ointments, and acetaminophen. The…

a patch of grass. The skin damage is often not deeper than the epidermis. It is often less severe compared to a laceration and if bleeding occurs it is very minimal. Mild abrasions are known as scrapes or brushes, while an abrasion that results in the removal of all skin layers refers to an avulsion. Injuries because of abrasion occur if moving exposed skin comes into contact with a rough surface leading to the removal of the epidermis upper layers. Occasionally, the direction of force may also…

Introduction The infection at the wound site is a severe kind of problem and it delays regeneration of epidermis and dermis in the wound and slows wound closure. Due to the secretion of microbial enzymes by wound pathogens, a variety of extracellular matrix proteins were degraded. Synthetic antimicrobial therapy used in the wound management and eradication of pathogens. However, it has many shortcomings such as anti-microbial resistance, cyto-toxicity against host tissue and absence of…

During this lab report, we observed the anatomy of a rat. Our task was to dissect a rat and identify its internal organs along with the function of those organs. We carefully removed 10 organs from our rat to take notes on. What we noticed was the homologous structures of the rats were closely related to our own body composition. Their internal organs were positioned in close relation to where ours takes shape, and they looked immensely similar. In addition to their location and size, the rat's…

Isolated Colonies and Soil Samples A. Purification of Serratia marcescens and Staphylococcus epidermis The objective was to grow isolated colonies on a nutrient agar medium (NA). Many microorganisms found in soil are able to grow on this medium. Since there are many organisms that are found in the soil, only a few of this organisms are adapted to live in this specific medium obtained. The NA plate is the first way to isolate microorganisms because the organisms that will be left on the plate…

performs a variety of functions to protect against the environment such as microorganisms, bacteria, UV radiation and harmful chemicals. It also provides sensory information and consists of three layers, the epidermis, dermis and the subcutaneous (hypodermis) layers (Marieb & Hoehn, 2007). The epidermis layer is a superficial layer of the skin and is the most important. It consists of dead cells on the surface…