Emphysema

Mixed contamination of PAHs and metals occur ubiquitously in the environment, but their combined toxicity to humans and other organisms are not fully addressed. The data from epidemiological, animal and in vitro studies indicated the nature of interaction between PAHs and metals varies from synergism to additivity or antagonism. In this chapter, the combined toxicity of PAHs and metals on toxicokinetic and toxicodynamic endpoints, and possible mechanism of actions were discussed. In addition,…