Doxorubicin

created by M. Varma, 200522. TPGS has been incorporated into various drug formulations partly because of its ability to overcome multidrug resistance (MDR). By inhibiting P-glycoprotein (P-gp) activity, the relative cytotoxicity of drugs such as doxorubicin, vinblastine, and paclitaxel was increased19. P-gp is a drug efflux pump, a.k.a. multidrug resistance protein 1 (MDR1), located in the cell membranes of distinct tissues throughout the body that transports a wide range of molecules in an…

Hodgkins Lyphoma According to the American Cancer Society more than 8,500 americans are diagnosed with Hodgkins Lymphoma each year occurring in people aged between 16 and 34 years of age and those over the age of 55. Lymphoma is a term defined as a type of cancer that develops in the lymphatic system which is part of our immune system. Hodgkins Lymphoma starts off by first developing in the white blood cells, developing in the lymph nodes and then spreading to any organ which includes the skin…

Cancer Medicine (Oncology) Cancer cells arise from different normal cells, thus when the normal cells become abnormal, it allows the cancer cells to grow out of control. Cancers can start almost anywhere in the human body, it can occur in any tissue and at any time of life, but mostly, elders have the highest risk. Cancers are called neoplasm because neoplasm is new growths that arise from normal tissue. Furthermore, there are two different characteristics of neoplasm: benign and…

Acute lymphoblastic leukemia (ALL), a cancer of the blood that is common in young children is currently incurable and has a high relapse rate amongst children (between the ages of 1-15 years), specifically boys. To elaborate, this disease is the cancer of white blood cells (WBCs) in which the body (depending on the type of ALL) over produces an abundance of immature lymphocytes in the bone marrow altering the immune system (i.e. the immune system becomes susceptible to infections, improper…

replaced with a non-diseased one from a donor. Furthermore, like all cancers, the main method of treating liver cancer is chemotherapy, where the drugs are entered intravenously; common drugs used for chemotherapy in liver cancer are sorafenib and doxorubicin. Another method of treatment is called tumor ablation, where the malignant cells would be deprived of nutrients; this would lead to…

an excessive charge and an extended disease regression have been achieved with chemotherapy after HAE. therefore, cytostatic sellers were introduced to this approach ensuing in hepatic artery chemoembolization (HACE). The most typically used are doxorubicin, mitomycin C, streptozin, and cisplatin. HACE providers now not best the embolic blocking off, but additionally the deliver of direct chemotherapy to those cells, increasing the motion/concentration of those sellers (greater than 20 times of…

Intrapleural Chemotherapy for Treating Mesothelioma Intrapleural perfusion of heated chemotherapy (ITH) is the chest counterpart of heated intraperitoneal chemotherapy (HIPEC). It is part of a surgical strategy traditionally used to treat pleural mesothelioma. Treating Pleural Mesothelioma Intrapleural chemotherapy can be given into the pleural cavity (the space between the lung and the lining of the lung). It is normally reserved for patients with very advanced disease, for which treatment…

3-hydroxyflavone, O-methyl phloretin, O-methyl luteolin, three mono- di- and tri-methylated genisteins, O-methyemodin and aloe-emodin were detected. Likewise, while analyzing the in vitro reaction mixture with sterol (β-sitosterol) and anthracyclines (doxorubicin and daunorubicin), the mass spectra of methoxy β-sitosterol, mono-, and di-O-methyl daunorubicin were obtained. This suggested the versatility of SpOMT7740 to accept different classes of natural products (flavonoids, sterols,…

Acute Lymphocytic Leukemia Everyone carries cancer cells throughout their body. The human body is programmed to fight off these cancer cells with natural immune defenses. For some, cancer is inevitable and can be brought upon in many different ways. One of the top 10 most common cancers is leukemia (Leukemia, p.1). While all leukemia is cancer of the blood cells, it can come in many different forms such as Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia, Chronic Lymphocytic Leukemia and…

be treated with the chemotherapy regimens cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) or etoposide, prednisone, vincristine, cyclophosphamide and hydroxydaunorubicin (EPOCH). They also recommend the concurrent use of HAART and a drug called rituximab. The suggested treatment for BL is similar to that of DLBCL. The researchers recommend the chemotherapy regimens EPOCH and cyclophosphamide, vincristine, doxorubicin, methotrexate, ifosfamide, etoposide, and cytarabine…