Doxorubicin

As a result, doctors began treating patients with chemotherapy before and after surgery (6). For about ten weeks prior to a patient’s surgical procedure, drugs such as doxorubicin and cisplatin are given to patients in an attempt to shrink the tumor to a smaller size before the mass is removed (3). After surgery, patients continue to undergo chemotherapy for up to a year. Depending on how the person responded to the drugs…

lines: HCT, HepG2 and MCF-7 where the cell viability, measured by SRB assay, and the IC50 was found to be 91, 80, 63 µg/ml respectively (Figure 3). The standard used was doxorubicin, which gave an IC50 value of 5.87, 4.19 and 3.83 µg/ml on each cell line respectively. Figure 3. Cytotoxic effect of pulchranin A (1) and doxorubicin (2) on HEPG2 (a), HCT (b) and MCF-7 (c) cell lines. The ability of pulchranin A to inhibit CDKs enzymes (Figure 4) was assessed on human breast cancer cell lines…

Breast cancer in females TERMINOLOGY CLINICAL CLARIFICATION ? Malignancy that develops in the cells of the breast which proliferates uncontrollably; most commonly ductal and lobular carcinoma ? Diagnosis requires a tissue biopsy for microscopic examination to determine pathology CLASSIFICATION ? The TNM classification is used for clinical staging of breast tumors. The American Joint Committee on Cancer (AJCC) 7th edition stages breast cancer as follows:?26 ? TX: primary tumor cannot be…

causes includes heart conditions (coronary heart disease, heart attack, high blood pressure), chronic metabolic diseases (diabetes, thyroid disease), infections (viral hepatitis and HIV), toxins like cobalt, alcohol, drugs (cocaine, amphetamines, doxorubicin and daunorubicin), and postpartum complications (American Heart Association…

cancer cell. Blood is taken from a patient. The platelets are collected from that blood. The isolated platelets are treated to extract the platelet membranes, which are then placed in a solution with a nanoscale gel containing the anticancer drug doxorubicin (Dox), which attacks the nucleus of a cancer cell. The solution is compressed, forcing the gel through the membranes and creating nanoscale spheres made up of platelet membranes with Doxgel cores. These spheres are then treated so that their…

severe side effect of DOX therapy. Previous studies demonstrate that cardiomyocyte death through apoptosis, necrosis, and other forms is a primary contributor to the development of DOX-induced cardiomyopathy(Zhang et al.,2009) The anthracycline doxorubicin-induced myocyte apoptosis is mediated by oxy radical chemistry. and change in level of antioxidant in the heart tissues(increase in CAT ,SOD and decrease level of GSH). On the other hand, a significant increase was observed in GSH…

will receive depend on the stage of lymphoma he is at and if he can bare the side effects. The drugs that the boy will receive will be given to him intravenously, some of the drugs that will be given to him are: cyclophosphamide, vincristine, doxorubicin, methotrexate and cytarabine, chemotherapy can also be given through into the spinal fluid to reach the spinal cord and central nervous system. This is either done to prevent the lymphoma cells from spreading into the cerebrospinal…

baseline. Different chemotherapy regimens were used in the treatment of patients with the different lymphoma subtypes (DLBCL, follicular lymphoma, other lymphoma subtypes). Among them, 77% (48) patients received rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), 13% (8) received rituximab in combination with prednisolone, vincristine and cyclophosphamide and 10% (6) received other chemotherapy…

1. Introduction Abortion is one of the most vital decisions and ethical argumentative issue especially in case of Pregnancy-associated breast cancer which is the most common solid tumor in pregnancy, it develops during pregnancy period or within 1 year after pregnancy, and presents both diagnostic and therapeutic dilemma. (Beadle, Wendy,Woodward, Lavinia, Middleton,Tereffe, et al., 2009). Approximately 0.2-3.8% of breast cancers in women under the age of 50 are diagnosed during pregnancy this…

ovarian cancer never dreamed. Ovarian cancer causes more deaths than any other gynecologic cancer in the United States. “FDA approved bevacizumab solution for intravenous infusion (Avastin) in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, for treatment of patients with platinum-resistant recurrent epithelian ovarian, fallopian tube, or primary peritoneal cancer”,…