Dopamine receptor

Transporter proteins comprise 5% of all human drug targets. This category encompasses the ATP-binding cassette (ABC) transporter family, ATPases, and the solute carrier (SLC) family. SLC6 is the most exploited family among all transporters (55%), with approximately 42 drugs currently approved by the US Food and Drug Administration (FDA) (Figure 4.9a)76. Currently, around 60 clinical trials are in progress for drugs that specifically target SLC6 family members, mainly for analgesia, psychiatric…

Depressants are one of the main drug category. They are used to experience euphoria or with other drugs to add to the other drugs’ high or to deal with their side effects. Depressants bring you down and suppress brain function, the effect of this is it will put you to sleep, relieve anxiety and muscle spasms, and prevent seizures.Other effects over a longer time can be depressants cause amnesia, leaving no memory of events that occur while under the influence, reduce your reaction time, impair…

We hypothesized that there are common gene pathways responsible for the schizophrenia–type 2 diabetes mellitus association in drug-naive subjects. In particular, wepropose that the insulin growth factor 2 m-RNA binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579 .associates and replicated in type 2 diabetes mellitus Egyptians (14,15) gene pathways maycontribute to both type 2 diabetes mellitus and schizophrenia Through this exploration , we tried to link thepathogenetic…

administration the time it takes to affect the body will vary. Eventually the drug gets distributed to the rest of the body via the bloodstream. This stimulant, when abused, can wreak havoc on the brain and body because it increases the synaptic levels of dopamine, serotonin (5-HT), and norepinephrine and has adrenergic agonist effects. It affects the entire body through the loss of hair, to irregular heartbeat, and finally to involuntary muscle spasms. Meth is metabolized through the liver and…

The focus of the research was to understand if cerebral dopamine neurotrophic factor (CDNF) has the ability to protect and restore dopaminergic neurons in the nigrostriatal system following the injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The research was conducted because there has not been a study conducted on the MPTP Parkinson’s disease model with the treatment of CDNF. C57/B16 mice were used as the research subjects. The hypothesis was first tested by injecting the…

noticeable. However, I began to notice an unusual behavior with the schizophrenia patients. They were not cooperating with the psychiatrist when interacting with the doctor. I remembered my professor in neuroscience class, emphasized on dopamine. He stated that the excess dopamine causes schizophrenia. Most of the schizophrenia patients are usually paranoid that someone is going to hurt them, so they find ways to prevent that such as having weapons with them. Also, in the abnormal psychology, I…

for funding. So, what is Parkinson’s disease? Well Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by tremors, rigidity, bradykinesia, and postural instability due to a deficiency of the neurotransmitter dopamine. Every single one of these characteristics affects individuals with PD in many ways, these symptoms vary from one person to another, some people may experience it differently. However, these symptoms are only one aspect of this multifaceted…

Introduction: It is hypothesized that irregular signaling that is regulated by the PDE4B gene plays a role in the expression of symptoms certain neuropsychiatric diseases (i.e. Schizophrenia and Bipolar disorder). Methods: 878 patients with schizophrenia or schizoaffective disorder were analyzed in the study, 644 were Caucasian and 234 were African American(AA). 604 controls subjects were also included, 407 Caucasian and 197 African American. All non-control patients were diagnosed by clinical…

This causes the nervous system cells to die, but the scientist is still trying to discover why these cells are dying. The question you might be thinking now is what is dopamine? Is it a drug or a chemical? Google defines dopamine as “a compound present in the body as a neurotransmitter and a precursor of other substances including epinephrine. “Sometimes repeated head trauma can increase the chances of getting this disease. One of the greatest heavyweight…

cure, the treatment offered to the patients is purely temporary, to control the side-effects. Also, there is no exact cause for this disease, it could very well be genetic, or derived. For the most part, however, scientist believe that a lack of dopamine in the substantia nigra area of the brain may be the primary cause of PD. Genetics and age are also two other factors to be considered. Age cannot be used as the only factor since “about 10 percent of the nearly 1 million people living with the…