Dopamine receptor

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  • Dopamine D2 Receptor Agonist Case Study

    Dopamine D2 receptor agonists Bromocriptine quick release (QR) is a dopamine D2 receptor agonist licensed in some countries outside Europe for treatment of T2DM as an adjunct to lifestyle changes . The effect of bromocriptine on glycaemic parameters has been noted since 1980. The drug provides a morning boost to hypo¬thalamic dopamine levels, consistent with normal diur¬nal glucoregulation, and contributing to a reduction of sympathetic tone, neural suppression of hepatic glucose production and improvement in peripheral glucose disposal, without affecting insulin levels. 10.1 Bromocriptine as monotherapy In two 6-month trials, overweight or obese individuals with type 2 diabetes were randomized to receive bromocriptine monotherapy or diet. Compared with diet alone, the average change in HbA1c and FPG from placebo was −0.4% and −27 mg/dl, respectively, in a population with an average baseline HbA1c of 8 – 9%. Bromocriptine treated patients were more likely to achieve a 1% decline in HbA1c (28%) from baseline compared with diet alone (8%) and to have a reduction in PPG compared with diet (p < 0.002). 10.2 Bromocriptine in combination A meta-analysis showed that bromocriptine QR add on therapy, compared with placebo, reduced levels of HbA1c (−6.52 mmol/mol,…

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  • Parkinson's Disease Causes

    of Parkinson’s, so therefore a person may lose interest in eating good food. It may be difficult to eat because of the impaired movement as well. If a person is taking medication for parkinson’s, there will often be the side effect of nausea and vomiting. This could be extremely hazardous to the health of the patient if they do not have good nutrition. (Fallon and Cataldo, 2013) The various medications that patients can receive are different and vary in accordance to other health factors. The…

    Words: 1883 - Pages: 8
  • Pathophysiology Of Methamphetamine

    increases release of neurotransmitter dopamine that is involved in reward and generation of pleasurable emotions (Volkow, 2001). Repeated use of methamphetamine causes excessive release of dopamine and results in the loss of behavioural control (Volkow et al., 2007). This report will first introduce physiology of reward and pleasure and role of neurotransmitter…

    Words: 904 - Pages: 4
  • The Role Of Neurotransmitter Dopamine Upon Behavior

    neurotransmitter Dopamine upon behaviour Neurotransmitters are molecules which communicate information between neurons and their target cells across small biological junctions, called chemical synaptic (Comer, 2013). Within the brain there are many different neurotransmitters which send different electrical signals to other areas within the brain, which control many different functions of the human body. Dopamine is commonly associated with the feelings of pleasure, this is because dopamine is…

    Words: 1767 - Pages: 8
  • Alcohol And Gba

    Alcohol has a significant effect on the brain, acting on neurons and various neurochemicals. It can modify cell membranes, along with their ion channels, enzymes and receptors. Alcohols’ effect on the central nervous system (CNS) is largely due to its action on different neurotransmitters. A major inhibitory neurotransmitter in the central nervous system is gamma-aminobutyric acid (GABA). Alcohol amplifies the effect of GABA by binding to and stimulating GABA receptors, causing the opening of…

    Words: 267 - Pages: 2
  • Prostate Cancer Case Study

    be repaired. Etoposide is a podophyllotoxin that inhibits topoisomerase II, the enzyme responsible for unwinding the DNA. If the DNA cannot unwind, the cell will be unable to replicate, transcribe mRNA, or repair itself. If the cell is unable to repair it will undergo apoptosis. The final treatment is flutamide, an anti-androgen, which inhibits the androgen receptor. The tumor is androgen positive which means testosterone stimulates the neoplasia to grow. Flutamide blocks the androgen receptors…

    Words: 1221 - Pages: 5
  • Evolution Of Dopamine

    Introduction According to Yamamoto and Vernier (2011), dopamine is without a doubt one of the oldest neurotransmitters acting on the central nervous system. The researchers suggest that the emergence of dopaminergic systems most likely predates the divergence of chordates during evolution, and the neurotransmitter’s common ancestry is suggested by commonalities among different species that express the same enzymes, vesicle transporters, degradation enzymes, and receptors. Since dopamine is a…

    Words: 1120 - Pages: 5
  • ADHD Stereotypes

    subtypes, which impair the ability to hold an attention span, have also become increasingly more diagnosed and less stigmatized. As such, an interest in researching how the brain goes about creating and mainting attention, as well as ways in which it can be improved, have been target areas of research in recent decades. How exactly the brain goes about creating attention is still largely unknown. What is known, however, is that levels of neurotransmitters in certain areas of the brain are…

    Words: 885 - Pages: 4
  • Antipsychotic Case Studies

    I. Over view of anti-psychotics Antipsychotics are used primarily to help treat people who suffer from hallucinations or dilations. This includes individuals who suffer from Schizophrenia, Bi polar disorder, Dementia or unipolar depression. Antipsychotics can be broken down in to two different categories, Atypical and Typical however they tend to work similarly over all. The main standing difference between the two categories is that atypical antipsychotics block dopamine and have an effect on…

    Words: 781 - Pages: 4
  • Research Paper On Chronic Depression

    the limbic are so important and complex that disturbances in any part of it, including how neurotransmitters function, could affect your mood and behavior. Depression and Neurotransmitters Prior studies have shown that there is link between depression and pain, and due to the association between depression and pain, studies have focused on dopaminergic areas of the brain, which can be malfunctioning in depression (Taylor, 2015). The mesolimbic dopamine system, consisting of dopamine neurons in…

    Words: 1807 - Pages: 8
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