DNA replication

telomere biology has become one which many are deciding to take on. We know that proper replication of the telomeric DNA at chromosome ends is critical for…

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C-terminal domain contains a significantly deep cleft, with a considerable area to enable the binding of the B-DNA. The overall domain itself is shaped almost like a cupped right hand where, in this case, α-helices on either side of the cleft form the thumb and fingers, while the β sheet forms the palm of the hand. Q3) What secondary structures make up the…

Structure of DNA: The Double Helix Introduction: DNA stands for DeoxyriboNucleic Acid. It is a type of Nucleic Acid, which has deoxyribose sugar in it instead of ribose. DNA has a double helical structure. By double helix, the meaning is two strands of polynucleotide running parallel and coiled around each other through hydrogen bonding. DNA is hereditary material in all the living organisms on this planet. The basic mystery behind its heredity nature resides in the same double helical structure…

Epstein - Barr virus or, Human herpesvirus 4, is the virus that causes infectious mononucleosis, and contains double-stranded DNA. This virus is species specific in that it only infects humans. The Epstein-Barr virus was discovered in 1964 when Michael Anthony Epstein and Yvonne Barr found it in a Burkitt lymphoma cell line. In 1968, they then linked the virus to the disease infectious mononucleosis. Once the host is infected with the virus it stays in the host for the remainder of the host’s…

epithelial cells increase the surface area and hence the rate of absorbance of molecules in to cells and the blood stream. DNAs function is highly specific to its structure as even the smallest change to this could cause a long term effect, or even death. Base sequence mutations, errors in replication and environmental factors are the main cause of changes to DNA. The structure of DNA was first discovered by James D. Watson and Francis Crick, and in 1962 they won the Nobel prize for discovering…

expression of approximately 25% of the 553 cell cycle-regulated genes in the genome (Reisenaur et al., 1999). This protein also blocks initiation of DNA replication by binding to five sites within the chromosomal origin (Brilli et al.,2010). During the G1 phase when C. crescentus transitions from swarmer cells to stalked cells, ctrA suppresses replication in the swarmer…

FPV is in the family Parvoviridae, which contains 26 species of virus that infect a broad host range, covering species from invertebrates to humans. Parvoviruses are small single stranded DNA viruses enveloped by a T=1 non-enveloped capsid protein. Replication of these viruses can only occur when the host cell is in S-phase of its mitotic cycle (15). FPV has a very small linear genome that is only 5 kilobases in length (4). The virus’s genome has specific sequences, similar to a TATA boxes, that…

classification of viruses as living organisms. For: viruses are classified as living organisms due to their possession of DNA or RNA in their systems. DNA and RNA are essential components of any living organism. Against: Viruses are only alive when they are present and depend on another living organism/host. 8. (4 points) Discuss the differences between…

adverse effects and increase of the efficacy of an anticancer drug. One of the most common chemotherapeutic drugs is doxorubicin (DOX), that is anthracycline antibiotic which inhibits DNA and proteins synthesis. DOX indicates antitumor activity through inhibition of topoisomerase II; as a result, it inhibits the replication…