Dissociation constant

the laws of thermodynamics. As a catalyst doesn’t change the equilibrium constant of a reaction but only modifies the approach towards equilibrium, in order to enhance reaction velocity, in same way, even a so-called ‘one way enzyme’ is constrained to maintain the same equilibrium constant in either direction. Haldane has successfully put together kinetic parameters (dependent on enzyme properties) and equilibrium constant (independent of enzyme properties) into what is known as the ‘Haldane…

allowed us to create a Dixon Plot as seen in Figure 4. This Figure showed the largest source of error and actually had a negative slope. A positive slope was expected, thus making our calculation for -Ki rather difficult. –Ki represents the dissociation constant for the complexes created in this experiment (enzyme-substrate and enzyme-substrate-inhibitor) and using the x-intercept of Figure 4 we determined that this value was -1.8081849. This value, as shown in Table 6, should have been a…

Classified as a complex brain disease, SUD is treatable, according to the USA National Institute of Drug Abuse (NIDA) principles of treatment [NIDA, 2008]. Given the aforementioned multiple factors, contributing to the development of SUD, its complex presentation, and associated disease burden; treatment of SUD is rated as significantly challenging. Delivering effective SUD treatment and care requires a comprehensive response, illustrated as core services and interventions delivered, within a…

which were examined through different tasks that show a functional dissociation between vigilance and selection attention. Vigilant attention reaction times showed a general trend that as fatigue increases, the accuracy of the task decreases as errors increase, and overall reaction time increases as attention decreases. Contrastingly, sleep deficiency in the selective attention task showed no affects, as search rate remained constant with or without sleep loss. Going forth, the challenge for…

The guilt built up and relentlessly harassed Amir through nightmares and memories. To eliminate any reminders, Amir did everything he could to eliminate Hassan from his life in attempt to forget the overwhelming guilt. Hassan being a constant reminder Amir’s worst memory was just one of the reasons Amir resented him, but the primary reason was Baba. Amir constantly pursued Baba’s approval, but Baba wanted Amir to be good at sports and essentially be more like Hassan. Hassan was athletic…

innate protein particles or aggregates.However, there is a mechanistic difference between the two aspects. In the case of a pure solubility issue, i.e. a protein becomes insoluble in a certain solution (no changes in protein structure and integrity) and a solid phase is formed, a strong dilution of the system may lead to the dissolution of the protein. In such a circumstance, the term “protein associates” may more appropriately describe the formed protein solid .In this instance, protein…

While the high dielectric constant favors salt dissociation, the low viscosity would lead to high ionic mobility in the electrolytic solution is formed by dissolving the two ionic salts in the EC/PC co-solvent [13]. From Fig. 1, the activation energy values, which correspond to the Arrhenius plot, are almost constant for all six gel electrolyte samples studied and independent of the salt concentration ratios (TBAI/LiI)…

The general aim of the study was to use Pymol to analyse molecular graphics of the isoenzymes carbonic anhydrase (CA) I and II, CA substrates (e.g. bicarbonate), and CA selective inhibitors (e.g., sulfonamides) to determine the relationship between CA structure and function. The specific aim of the study, described in part (ii), was to use Pymol to analyse molecular graphics of CA-I, and II, to determine relationship between structure and function and then use the results to analyse how one of…

Early studies on the lateral diffusion of rhodopsin in ROS membranes resulted in viewing this visual receptor as monomeric entity freely diffusing in a phospholipid bilayer (Calvert et al., 2001; Chabre et al., 2003; Liebman et al., 1982; Poo and Cone, 1974). However, it is important to stress that the movement of rhodopsin restricted to approximately two-dimensional environment of membranous phospholipid bilayer would rather reduce its dynamic freedom by orders of magnitude relative to soluble…

Diagnosing the Defense One of the hallmarks of being human that separates people from other species is the constant need for understanding the surrounding world. In order to feel as if they are in control, people must find a sense of mastery over the universe and their environment, and this is done by interpreting information they receive. Simply put, an interpretation is an explanation of a certain phenomenon. Psychologist Leslie Bell, uses this sort of interpretation to understand why women…