Disseminated intravascular coagulation

Budget Justification Personnel Vijaya M. Lella (also known as L. Vijaya Mohan Rao), Ph.D. Principal Investigator, 3.6 calendar months effort and salary. The P.I. will devote 30% of his effort on the proposed grant. He will assume overall responsibility for the proposed project, which includes supervision of all personnel involved in the project, planning, the design of experimental approaches, the close review of the data, data analysis & interpretation, preparation of manuscripts, and decisions…

SIMULATION CROSS BETWEEN A HETEROZYGOUS FEMALE AND A HEMOPHILIA MALE BACKGROUND INFORMATION The survival of the human species throughout the last millions of years has been solely based on the randomized process of genetic inheritance from one generation to the next generation. Instead of duplicating their genetic information and create identical offspring, humans produce sex cells, through the process of meiosis, that carry only half of the genetic information, and fertilize them in order to…

Hemophilia is a medical condition in which the ability of the blood to clot is severely reduced causing the sufferer to bleed severely from even a slight injury. There are four types of Hemophilia which are Hemophilia A-Also called classic hemophilia, it is four times more common than Hemophilia B, and it occurs when factor VIII levels are deficient, Hemophilia B-Also called christmas disease, it occurs when factor Xi levels are deficient, Hemophilia C-It occurs when facts of XI levels are…

comes in contact with agents which activates the contact factors. PTT assesses intrinsic and common pathway of coagulation. Prothrombin time ( PT) measures the time needed for plasma to form a clot in the presence of tissue factor. PT evaluates extrinsic and common pathway of coagulation (Zehnder, 2017). In Hemophilia, the deficient factors are related to the intrinsic cascade of coagulation, therefore PTT is prolonged and abnormal. b. In which gender is this disorder common and why? • This…

According to the Center for Disease Control and Prevention, Hemophilia affects 1 in 5,000 male births which factor out to be about 400 babies born with hemophilia each year [3]. Hemophilia is classified as one of the oldest and longest lifelong bleeding disorders that are inherited, meaning passed down from parents to their children. This disorder occurs when the protein in the blood or platelets that assists the blood to clot is absent or not functioning properly, resulting in extended bleeding…

Hard dreamer age 25 male a case of frequent disruption to studies & parents under emotional & financial stress. As a kid “he cuts his small toe when he was one years old resulting in an unusual bleed,” (Ramchander, 2009). Then he starts “bleeding frequently from different sites like his gums, nose & ears,” (Ramchander, 2009). Three years later he bleeds from his forehead & hip after a fall, he experiences a major bleed in the urinary tract, & lastly his right knee is swollen making his movements…

A wise American poet, Roger Zelazny, once said “The power to hurt has evolved in a direct relationship to technological advancement.” It is 2016: advancements are endless, especially when it comes to horror films. Think of the famous 1897 horror film Dracula; the blood that looked like blobs of ketchup, the large amounts of makeup on the actors, it all seems so fake now. With advancements in technology producers are able to create horror films with undeniable visual effects. Better visual…

excessive, or even fatal bleeding. (galegroup.com) Number of people affected – It is estimated that 10,000 people are born with this disease. It is a lifelong and chronic illness. (google.com) Life Expectancy- as of 2015, hemophilia was the most common coagulation factor deficiency and also had the highest associated treatment cost for a disorder. Life expectancy for people with Hemophilia is the same for regular people, because there is effective treatment.…

Early vitamin K deficiency bleeding occurs in 1 and 60 newborns born in the first 0-24 hours after birth. Mothers who used certain medications during their pregnancy makes it a higher risk for early deficiency bleeding also making it more severe. Late vitamin K deficiency bleeding in 2-12 weeks after birth occurs in 1 in 14,000 infants. 30%-60% of these infants have bleeding within the brain and tend to occur in breastfed only babies who have not received the vitamin K shot. All pregnant…

“A Novel Application of Microfluidic Assay to Evaluate the Role of Calponin in Platelet Function and Clot Formation” Introduction: Platelets are a very important aspect of blood clotting. They are also essential in the evolution of clots in Coronary and Cerebral arteries, which cause heart attacks and strokes, respectively. Every year, 610,000 people die of heart disease in the United States; this is 1 in every 4 deaths. Cardiovascular disease is the number one cause of death in the United…